FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001682320> ?p ?o ?g. }

• W2001682320 endingPage "560" @default.
• W2001682320 startingPage "553" @default.
• W2001682320 abstract "Using luminescent conjugated polyelectrolyte probes (LCPs), we demonstrate the possibility to distinguish amyloid-beta 1-42 peptide (Abeta1-42) fibril conformations, by analyzing in vitro generated amyloid fibrils of Abeta1-42 formed under quiescent and agitated conditions. LCPs were then shown to resolve such conformational heterogeneity of amyloid deposits in vivo. A diversity of amyloid deposits depending upon morphology and anatomic location was illustrated with LCPs in frozen ex vivo brain sections from a transgenic mouse model (tg-APP swe) of Alzheimer's disease. Comparative LCP fluorescence showed that compact-core plaques of amyloid beta precursor protein transgenic mice were composed of rigid dense amyloid. A more abundant form of amyloid plaque displayed morphology of a compact center with a protruding diffuse exterior. Surprisingly, the compact center of these plaques showed disordered conformations of the fibrils, and the exterior was composed of rigid amyloid protruding from the disordered center. This type of plaque appears to grow from more loosely assembled regions toward solidified amyloid tentacles. This work demonstrates how application of LCPs can prove helpful to monitor aggregate structure of in vivo formed amyloid deposits such as architecture, maturity, and origin." @default.
• W2001682320 created "2016-06-24" @default.
• W2001682320 creator A5004653274 @default.
• W2001682320 creator A5012208856 @default.
• W2001682320 creator A5018345023 @default.
• W2001682320 creator A5021609201 @default.
• W2001682320 creator A5052435087 @default.
• W2001682320 creator A5054109471 @default.
• W2001682320 creator A5057210285 @default.
• W2001682320 creator A5069932768 @default.
• W2001682320 creator A5071769240 @default.
• W2001682320 creator A5083682264 @default.
• W2001682320 creator A5086283473 @default.
• W2001682320 creator A5090331352 @default.
• W2001682320 creator A5091716741 @default.
• W2001682320 date "2007-08-01" @default.
• W2001682320 modified "2023-10-10" @default.
• W2001682320 title "Imaging Distinct Conformational States of Amyloid-β Fibrils in Alzheimer’s Disease Using Novel Luminescent Probes" @default.
• W2001682320 cites W1532336307 @default.
• W2001682320 cites W1553423283 @default.
• W2001682320 cites W1964216949 @default.
• W2001682320 cites W1973758214 @default.
• W2001682320 cites W1978959047 @default.
• W2001682320 cites W1980094416 @default.
• W2001682320 cites W1981654394 @default.
• W2001682320 cites W1995247791 @default.
• W2001682320 cites W2004098528 @default.
• W2001682320 cites W2009418110 @default.
• W2001682320 cites W2016351953 @default.
• W2001682320 cites W2029203254 @default.
• W2001682320 cites W2044448989 @default.
• W2001682320 cites W2056666485 @default.
• W2001682320 cites W2058432632 @default.
• W2001682320 cites W2060215277 @default.
• W2001682320 cites W2069638680 @default.
• W2001682320 cites W2075815733 @default.
• W2001682320 cites W2085703547 @default.
• W2001682320 cites W2093861673 @default.
• W2001682320 cites W2098022922 @default.
• W2001682320 cites W2103440561 @default.
• W2001682320 cites W2152222652 @default.
• W2001682320 cites W2152278845 @default.
• W2001682320 cites W2165021720 @default.
• W2001682320 cites W2166892529 @default.
• W2001682320 cites W2171495114 @default.
• W2001682320 doi "https://doi.org/10.1021/cb700116u" @default.
• W2001682320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17672509" @default.
• W2001682320 hasPublicationYear "2007" @default.
• W2001682320 type Work @default.
• W2001682320 sameAs 2001682320 @default.
• W2001682320 citedByCount "177" @default.
• W2001682320 countsByYear W20016823202012 @default.
• W2001682320 countsByYear W20016823202013 @default.
• W2001682320 countsByYear W20016823202014 @default.
• W2001682320 countsByYear W20016823202015 @default.
• W2001682320 countsByYear W20016823202016 @default.
• W2001682320 countsByYear W20016823202017 @default.
• W2001682320 countsByYear W20016823202018 @default.
• W2001682320 countsByYear W20016823202019 @default.
• W2001682320 countsByYear W20016823202020 @default.
• W2001682320 countsByYear W20016823202021 @default.
• W2001682320 countsByYear W20016823202022 @default.
• W2001682320 countsByYear W20016823202023 @default.
• W2001682320 crossrefType "journal-article" @default.
• W2001682320 hasAuthorship W2001682320A5004653274 @default.
• W2001682320 hasAuthorship W2001682320A5012208856 @default.
• W2001682320 hasAuthorship W2001682320A5018345023 @default.
• W2001682320 hasAuthorship W2001682320A5021609201 @default.
• W2001682320 hasAuthorship W2001682320A5052435087 @default.
• W2001682320 hasAuthorship W2001682320A5054109471 @default.
• W2001682320 hasAuthorship W2001682320A5057210285 @default.
• W2001682320 hasAuthorship W2001682320A5069932768 @default.
• W2001682320 hasAuthorship W2001682320A5071769240 @default.
• W2001682320 hasAuthorship W2001682320A5083682264 @default.
• W2001682320 hasAuthorship W2001682320A5086283473 @default.
• W2001682320 hasAuthorship W2001682320A5090331352 @default.
• W2001682320 hasAuthorship W2001682320A5091716741 @default.
• W2001682320 hasConcept C102230213 @default.
• W2001682320 hasConcept C104317684 @default.
• W2001682320 hasConcept C121332964 @default.
• W2001682320 hasConcept C12554922 @default.
• W2001682320 hasConcept C141035611 @default.
• W2001682320 hasConcept C142724271 @default.
• W2001682320 hasConcept C150903083 @default.
• W2001682320 hasConcept C179104552 @default.
• W2001682320 hasConcept C185592680 @default.
• W2001682320 hasConcept C207001950 @default.
• W2001682320 hasConcept C27523624 @default.
• W2001682320 hasConcept C2777633098 @default.
• W2001682320 hasConcept C2779134260 @default.
• W2001682320 hasConcept C2779281246 @default.
• W2001682320 hasConcept C2779951007 @default.
• W2001682320 hasConcept C502032728 @default.
• W2001682320 hasConcept C55493867 @default.
• W2001682320 hasConcept C62520636 @default.
• W2001682320 hasConcept C68026918 @default.
• W2001682320 hasConcept C71924100 @default.
• W2001682320 hasConcept C86803240 @default.

• next