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• W2001692904 abstract "In this review, we discuss the role of endocytosis, a fundamental process internalizing molecules from the plasma membrane, and its critical importance in podocyte biology.Endocytic clathrin and nonclathrin-coated pits have been visualized in podocytes using electron microscopy, but the functional biological relevance has not been well defined. Recent evidence suggests that loss of key clathrin endocytic regulatory apparatus, such as dynamin, synaptojanin 1 or endophilin, in genetic mouse models of disease results in severe proteinuria and foot process effacement. In addition, several genes implicated in human nephrotic syndrome directly or indirectly associate with these endocytic proteins, thus creating a protein network that is linked in actin dynamics, signalling and endocytosis.This review summarizes our current understanding of membrane trafficking specifically in podocytes, thus giving further novel insights into the molecular mechanisms and pathogenesis of nephrotic syndrome." @default.
• W2001692904 created "2016-06-24" @default.
• W2001692904 creator A5019116609 @default.
• W2001692904 creator A5087257594 @default.
• W2001692904 date "2013-07-01" @default.
• W2001692904 modified "2023-09-23" @default.
• W2001692904 title "The function of endocytosis in podocytes" @default.
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• W2001692904 doi "https://doi.org/10.1097/mnh.0b013e3283624820" @default.
• W2001692904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4143890" @default.
• W2001692904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23703394" @default.
• W2001692904 hasPublicationYear "2013" @default.
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