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• W2001697057 endingPage "e1004622" @default.
• W2001697057 startingPage "e1004622" @default.
• W2001697057 abstract "Tick-borne encephalitis virus (TBEV) is transferred to humans by ticks. The virus causes tick-borne encephalitis (TBE) with symptoms such as meningitis and meningoencephalitis. About one third of the patients suffer from long-lasting sequelae after clearance of the infection. Studies of the immune response during TBEV-infection are essential to the understanding of host responses to TBEV-infection and for the development of therapeutics. Here, we studied in detail the primary CD8 T cell response to TBEV in patients with acute TBE. Peripheral blood CD8 T cells mounted a considerable response to TBEV-infection as assessed by Ki67 and CD38 co-expression. These activated cells showed a CD45RA-CCR7-CD127- phenotype at day 7 after hospitalization, phenotypically defining them as effector cells. An immunodominant HLA-A2-restricted TBEV epitope was identified and utilized to study the characteristics and temporal dynamics of the antigen-specific response. The functional profile of TBEV-specific CD8 T cells was dominated by variants of mono-functional cells as the effector response matured. Antigen-specific CD8 T cells predominantly displayed a distinct Eomes+Ki67+T-bet+ effector phenotype at the peak of the response, which transitioned to an Eomes-Ki67-T-bet+ phenotype as the infection resolved and memory was established. These transcription factors thus characterize and discriminate stages of the antigen-specific T cell response during acute TBEV-infection. Altogether, CD8 T cells responded strongly to acute TBEV infection and passed through an effector phase, prior to gradual differentiation into memory cells with distinct transcription factor expression-patterns throughout the different phases." @default.
• W2001697057 created "2016-06-24" @default.
• W2001697057 creator A5010988421 @default.
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• W2001697057 date "2015-01-22" @default.
• W2001697057 modified "2023-10-18" @default.
• W2001697057 title "Specificity and Dynamics of Effector and Memory CD8 T Cell Responses in Human Tick-Borne Encephalitis Virus Infection" @default.
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• W2001697057 doi "https://doi.org/10.1371/journal.ppat.1004622" @default.
• W2001697057 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4303297" @default.
• W2001697057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25611738" @default.
• W2001697057 hasPublicationYear "2015" @default.
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