Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001710079> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2001710079 endingPage "342" @default.
- W2001710079 startingPage "335" @default.
- W2001710079 abstract "In order to examine hepatic clearance of gastrointestinal regulatory peptides, rat livers were perfused in situ, and radiolabelled somatostain (S-14, S-28), gastrin-releasing peptide (GRP-14, GRP-27), and vasoactive intestinal peptide (VIP) were injected into the portal vein and hepatic venous effluent was collected. S-14 and S-28 were not affected significantly by hepatic transit: 91.6±2.8% (SEM) of S-14 and 95.9±2.2% of S-28 were recovered, and neither peptide was degraded by hepatic transit, as determined by immunprecipitation and gel chromatography. GRP-14 and GRP-27 were also not affected by hepatic transit: 91.5±1.6% of GRP-14 and 94.4±2.4% of GRP-27 were recovered intact. In contrast, when radiolabelled VIP was infused into the portal vein, 56.7±7.4% of injected labelled VIP appeared in the hepatic venous effluent, of which only 33.5±1.2% was intact peptide. Results of these studies indicate that enteric VIP released into the splanchnic/portal circulation is cleared by hepatic transit. However, somatostatin and GRP peptides appear to traverse the liver intact and could potentially produce systemic biological effects." @default.
- W2001710079 created "2016-06-24" @default.
- W2001710079 creator A5008778388 @default.
- W2001710079 creator A5055037445 @default.
- W2001710079 creator A5087290775 @default.
- W2001710079 date "1987-01-01" @default.
- W2001710079 modified "2023-09-26" @default.
- W2001710079 title "Hepatic clearance of somatostatin and gastrin-releasing peptide" @default.
- W2001710079 cites W125224816 @default.
- W2001710079 cites W1410549774 @default.
- W2001710079 cites W1695032273 @default.
- W2001710079 cites W1966722467 @default.
- W2001710079 cites W1967029335 @default.
- W2001710079 cites W1981488062 @default.
- W2001710079 cites W1992667476 @default.
- W2001710079 cites W1995625226 @default.
- W2001710079 cites W2001585030 @default.
- W2001710079 cites W2012122730 @default.
- W2001710079 cites W2033785962 @default.
- W2001710079 cites W2053295915 @default.
- W2001710079 cites W2058026777 @default.
- W2001710079 cites W2064671526 @default.
- W2001710079 cites W2118397914 @default.
- W2001710079 cites W2153422135 @default.
- W2001710079 cites W2159957932 @default.
- W2001710079 cites W317382823 @default.
- W2001710079 doi "https://doi.org/10.1016/0024-3205(87)90134-2" @default.
- W2001710079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2880271" @default.
- W2001710079 hasPublicationYear "1987" @default.
- W2001710079 type Work @default.
- W2001710079 sameAs 2001710079 @default.
- W2001710079 citedByCount "6" @default.
- W2001710079 crossrefType "journal-article" @default.
- W2001710079 hasAuthorship W2001710079A5008778388 @default.
- W2001710079 hasAuthorship W2001710079A5055037445 @default.
- W2001710079 hasAuthorship W2001710079A5087290775 @default.
- W2001710079 hasConcept C118303440 @default.
- W2001710079 hasConcept C126322002 @default.
- W2001710079 hasConcept C134018914 @default.
- W2001710079 hasConcept C170493617 @default.
- W2001710079 hasConcept C185592680 @default.
- W2001710079 hasConcept C2776165368 @default.
- W2001710079 hasConcept C2776297358 @default.
- W2001710079 hasConcept C2776986829 @default.
- W2001710079 hasConcept C2776998989 @default.
- W2001710079 hasConcept C2778448772 @default.
- W2001710079 hasConcept C2779281246 @default.
- W2001710079 hasConcept C49039625 @default.
- W2001710079 hasConcept C55493867 @default.
- W2001710079 hasConcept C56191518 @default.
- W2001710079 hasConcept C71924100 @default.
- W2001710079 hasConcept C8330315 @default.
- W2001710079 hasConcept C86803240 @default.
- W2001710079 hasConceptScore W2001710079C118303440 @default.
- W2001710079 hasConceptScore W2001710079C126322002 @default.
- W2001710079 hasConceptScore W2001710079C134018914 @default.
- W2001710079 hasConceptScore W2001710079C170493617 @default.
- W2001710079 hasConceptScore W2001710079C185592680 @default.
- W2001710079 hasConceptScore W2001710079C2776165368 @default.
- W2001710079 hasConceptScore W2001710079C2776297358 @default.
- W2001710079 hasConceptScore W2001710079C2776986829 @default.
- W2001710079 hasConceptScore W2001710079C2776998989 @default.
- W2001710079 hasConceptScore W2001710079C2778448772 @default.
- W2001710079 hasConceptScore W2001710079C2779281246 @default.
- W2001710079 hasConceptScore W2001710079C49039625 @default.
- W2001710079 hasConceptScore W2001710079C55493867 @default.
- W2001710079 hasConceptScore W2001710079C56191518 @default.
- W2001710079 hasConceptScore W2001710079C71924100 @default.
- W2001710079 hasConceptScore W2001710079C8330315 @default.
- W2001710079 hasConceptScore W2001710079C86803240 @default.
- W2001710079 hasIssue "4" @default.
- W2001710079 hasLocation W20017100791 @default.
- W2001710079 hasLocation W20017100792 @default.
- W2001710079 hasOpenAccess W2001710079 @default.
- W2001710079 hasPrimaryLocation W20017100791 @default.
- W2001710079 hasRelatedWork W1965368978 @default.
- W2001710079 hasRelatedWork W2020688170 @default.
- W2001710079 hasRelatedWork W2032638829 @default.
- W2001710079 hasRelatedWork W2057620180 @default.
- W2001710079 hasRelatedWork W2070722697 @default.
- W2001710079 hasRelatedWork W2081165789 @default.
- W2001710079 hasRelatedWork W2119151667 @default.
- W2001710079 hasRelatedWork W2131521086 @default.
- W2001710079 hasRelatedWork W2156990306 @default.
- W2001710079 hasRelatedWork W4242058110 @default.
- W2001710079 hasVolume "40" @default.
- W2001710079 isParatext "false" @default.
- W2001710079 isRetracted "false" @default.
- W2001710079 magId "2001710079" @default.
- W2001710079 workType "article" @default.