FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001712085> ?p ?o ?g. }

• W2001712085 endingPage "1262" @default.
• W2001712085 startingPage "1252" @default.
• W2001712085 abstract "The increased proliferation and migration of vascular smooth muscle cells (VSMCs) are key events in the development of atherosclerotic lesions. Baicalin, an herb-derived flavonoid compound, has been previously shown to induce apoptosis and growth inhibition in cancer cells through multiple pathways. However, the potential role of baicalin in regulation of VSMC proliferation and prevention of cardiovascular diseases remains unexplored. In this study, we show that pretreatment with baicalin has a dose-dependent inhibitory effect on PDGF-BB-stimulated VSMC proliferation, accompanied with the reduction of proliferating cell nuclear antigen (PCNA) expression. We also show that baicalin-induced growth inhibition is associated with a decrease in cyclin E-CDK2 activation and increase in p27 level in PDGF-stimulated VSMCs, which appears to be at least partly mediated by blockade of PDGF receptor β (PDGFRβ)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling. In addition, baicalin was also found to inhibit adhesion molecule expression and cell migration induced by PDGF-BB in VSMCs. Furthermore, using an animal carotid arterial balloon-injury model, we found that baicalin significantly inhibited neointimal hyperplasia. Taken together, our results reveal a novel function of baicalin in inducing growth arrest of PDGF-stimulated VSMCs and suppressing neointimal hyperplasia after balloon injury, and suggest that the underlying mechanism involves the inhibition of cyclin E-CDK2 activation and the increase in p27 accumulation via blockade of the PDGFRβ-ERK1/2 signaling cascade." @default.
• W2001712085 created "2016-06-24" @default.
• W2001712085 creator A5002622291 @default.
• W2001712085 creator A5003736471 @default.
• W2001712085 creator A5011109984 @default.
• W2001712085 creator A5012749274 @default.
• W2001712085 creator A5024445733 @default.
• W2001712085 creator A5066640962 @default.
• W2001712085 creator A5069186552 @default.
• W2001712085 creator A5090427438 @default.
• W2001712085 date "2010-07-27" @default.
• W2001712085 modified "2023-10-10" @default.
• W2001712085 title "Baicalin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation through suppressing PDGFRβ-ERK signaling and increase in p27 accumulation and prevents injury-induced neointimal hyperplasia" @default.
• W2001712085 cites W1915022454 @default.
• W2001712085 cites W1970543597 @default.
• W2001712085 cites W1972676329 @default.
• W2001712085 cites W1977065645 @default.
• W2001712085 cites W1980123375 @default.
• W2001712085 cites W1986222650 @default.
• W2001712085 cites W1987430295 @default.
• W2001712085 cites W1993487598 @default.
• W2001712085 cites W2006160253 @default.
• W2001712085 cites W2015754852 @default.
• W2001712085 cites W2028244585 @default.
• W2001712085 cites W2029080338 @default.
• W2001712085 cites W2044312503 @default.
• W2001712085 cites W2048635895 @default.
• W2001712085 cites W2063346526 @default.
• W2001712085 cites W2073853969 @default.
• W2001712085 cites W2110121929 @default.
• W2001712085 cites W2111423476 @default.
• W2001712085 cites W2118837782 @default.
• W2001712085 cites W2120310232 @default.
• W2001712085 cites W2124648016 @default.
• W2001712085 cites W2125678486 @default.
• W2001712085 cites W2126044750 @default.
• W2001712085 cites W2128679450 @default.
• W2001712085 cites W2137743724 @default.
• W2001712085 cites W2144232076 @default.
• W2001712085 cites W2145624529 @default.
• W2001712085 cites W2151668030 @default.
• W2001712085 cites W2152236137 @default.
• W2001712085 cites W2152398347 @default.
• W2001712085 doi "https://doi.org/10.1038/cr.2010.111" @default.
• W2001712085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3193477" @default.
• W2001712085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20661261" @default.
• W2001712085 hasPublicationYear "2010" @default.
• W2001712085 type Work @default.
• W2001712085 sameAs 2001712085 @default.
• W2001712085 citedByCount "80" @default.
• W2001712085 countsByYear W20017120852012 @default.
• W2001712085 countsByYear W20017120852013 @default.
• W2001712085 countsByYear W20017120852014 @default.
• W2001712085 countsByYear W20017120852015 @default.
• W2001712085 countsByYear W20017120852016 @default.
• W2001712085 countsByYear W20017120852017 @default.
• W2001712085 countsByYear W20017120852018 @default.
• W2001712085 countsByYear W20017120852019 @default.
• W2001712085 countsByYear W20017120852020 @default.
• W2001712085 countsByYear W20017120852021 @default.
• W2001712085 countsByYear W20017120852022 @default.
• W2001712085 countsByYear W20017120852023 @default.
• W2001712085 crossrefType "journal-article" @default.
• W2001712085 hasAuthorship W2001712085A5002622291 @default.
• W2001712085 hasAuthorship W2001712085A5003736471 @default.
• W2001712085 hasAuthorship W2001712085A5011109984 @default.
• W2001712085 hasAuthorship W2001712085A5012749274 @default.
• W2001712085 hasAuthorship W2001712085A5024445733 @default.
• W2001712085 hasAuthorship W2001712085A5066640962 @default.
• W2001712085 hasAuthorship W2001712085A5069186552 @default.
• W2001712085 hasAuthorship W2001712085A5090427438 @default.
• W2001712085 hasBestOaLocation W20017120851 @default.
• W2001712085 hasConcept C126322002 @default.
• W2001712085 hasConcept C134018914 @default.
• W2001712085 hasConcept C170493617 @default.
• W2001712085 hasConcept C179998833 @default.
• W2001712085 hasConcept C180361614 @default.
• W2001712085 hasConcept C185592680 @default.
• W2001712085 hasConcept C190283241 @default.
• W2001712085 hasConcept C199835354 @default.
• W2001712085 hasConcept C2775960820 @default.
• W2001712085 hasConcept C2778095995 @default.
• W2001712085 hasConcept C2778283817 @default.
• W2001712085 hasConcept C2778583881 @default.
• W2001712085 hasConcept C2779395532 @default.
• W2001712085 hasConcept C2780113650 @default.
• W2001712085 hasConcept C29537977 @default.
• W2001712085 hasConcept C2992686903 @default.
• W2001712085 hasConcept C43617362 @default.
• W2001712085 hasConcept C502942594 @default.
• W2001712085 hasConcept C55493867 @default.
• W2001712085 hasConcept C57074206 @default.
• W2001712085 hasConcept C62112901 @default.
• W2001712085 hasConcept C62478195 @default.
• W2001712085 hasConcept C71924100 @default.
• W2001712085 hasConcept C86803240 @default.
• W2001712085 hasConcept C95444343 @default.
• W2001712085 hasConcept C98274493 @default.

• next