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• W2001717748 abstract "The s-Myc is similar to c-Myc in its ability to induce apoptosis requiring caspase activation. However, s-Myc is distinct from c-Myc in that it has activity to suppress tumor growth and does not require wild-type p53 to induce apoptosis. These facts suggest differential regulation between s-Myc and c-Myc. Here we showed that s-Myc-mediated apoptosis triggered by UV was not inhibited by the inactive form mutant JNK (APF), though c-Myc-mediated apoptosis was. Moreover, we found that JNK did not affect the transactivation activity of s-Myc, but stimulated that of c-Myc. In contrast, both Myc-mediated apoptosis and caspase-3-like protease activation were suppressed by kinase-negative MKK6 and an inactive form mutant p38(AGF). Our results indicate that s-Myc does not require the JNK signaling unlike c-Myc during UV-triggered apoptosis, but the MKK6/p38MAPK pathway might regulate common apoptotic machinery for both s-Myc and c-Myc upstream of caspase." @default.
• W2001717748 created "2016-06-24" @default.
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• W2001717748 date "2000-01-01" @default.
• W2001717748 modified "2023-10-16" @default.
• W2001717748 title "Differential Role of the JNK and p38 MAPK Pathway in c-Myc- and s-Myc-Mediated Apoptosis" @default.
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• W2001717748 doi "https://doi.org/10.1006/bbrc.1999.1952" @default.
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