Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001736182> ?p ?o ?g. }
- W2001736182 endingPage "227" @default.
- W2001736182 startingPage "218" @default.
- W2001736182 abstract "Neural stem cells (NSCs) persist in the forebrain subventricular zone (SVZ) within a niche containing endothelial cells. Evidence suggests that endothelial cells stimulate NSC expansion and neurogenesis. Experimental stroke increases neurogenesis and angiogenesis, but how endothelial cells influence stroke-induced neurogenesis is unknown. We hypothesized intact or oxygen-glucose deprived (OGD) endothelial cells secrete factors that enhance neurogenesis. We co-cultured mouse SVZ neurospheres (NS) with endothelial cells, or differentiated NS in endothelial cell-conditioned medium (ECCM). NS also were expanded in ECCM from OGD-exposed (OGD-ECCM) endothelial cells to assess injury effects. ECCM significantly increased NS production. NS co-cultured with endothelial cells or ECCM generated more immature-appearing neurons and oligodendrocytes, and astrocytes with radial glial-like/reactive morphology than controls. OGD-ECCM stimulated neuroblast migration and yielded neurons with longer processes and more branching. These data indicate that intact and injured endothelial cells exert differing effects on NSCs, and suggest targets for stimulating regeneration after brain insults." @default.
- W2001736182 created "2016-06-24" @default.
- W2001736182 creator A5003678910 @default.
- W2001736182 creator A5024720824 @default.
- W2001736182 creator A5047243678 @default.
- W2001736182 creator A5050051706 @default.
- W2001736182 date "2010-01-01" @default.
- W2001736182 modified "2023-10-15" @default.
- W2001736182 title "Intact and injured endothelial cells differentially modulate postnatal murine forebrain neural stem cells" @default.
- W2001736182 cites W1838072560 @default.
- W2001736182 cites W1965681567 @default.
- W2001736182 cites W1969205319 @default.
- W2001736182 cites W1970948890 @default.
- W2001736182 cites W1974262918 @default.
- W2001736182 cites W1977389640 @default.
- W2001736182 cites W1979612418 @default.
- W2001736182 cites W1980286364 @default.
- W2001736182 cites W1981829804 @default.
- W2001736182 cites W1983319708 @default.
- W2001736182 cites W1987554991 @default.
- W2001736182 cites W2003644243 @default.
- W2001736182 cites W2004381763 @default.
- W2001736182 cites W2011823445 @default.
- W2001736182 cites W2023331971 @default.
- W2001736182 cites W2026990513 @default.
- W2001736182 cites W2029477657 @default.
- W2001736182 cites W2035848392 @default.
- W2001736182 cites W2044398078 @default.
- W2001736182 cites W2051021067 @default.
- W2001736182 cites W2052316576 @default.
- W2001736182 cites W2057269156 @default.
- W2001736182 cites W2062253564 @default.
- W2001736182 cites W2068896673 @default.
- W2001736182 cites W2075317738 @default.
- W2001736182 cites W2079365338 @default.
- W2001736182 cites W2089425745 @default.
- W2001736182 cites W2091457385 @default.
- W2001736182 cites W2109503237 @default.
- W2001736182 cites W2134217567 @default.
- W2001736182 cites W2134717451 @default.
- W2001736182 cites W2139450672 @default.
- W2001736182 cites W2143058635 @default.
- W2001736182 cites W2150921745 @default.
- W2001736182 cites W2160862072 @default.
- W2001736182 cites W2168272960 @default.
- W2001736182 cites W2395431196 @default.
- W2001736182 cites W4254329016 @default.
- W2001736182 cites W4254868516 @default.
- W2001736182 cites W4255057869 @default.
- W2001736182 doi "https://doi.org/10.1016/j.nbd.2009.10.008" @default.
- W2001736182 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2854548" @default.
- W2001736182 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19837162" @default.
- W2001736182 hasPublicationYear "2010" @default.
- W2001736182 type Work @default.
- W2001736182 sameAs 2001736182 @default.
- W2001736182 citedByCount "51" @default.
- W2001736182 countsByYear W20017361822012 @default.
- W2001736182 countsByYear W20017361822013 @default.
- W2001736182 countsByYear W20017361822014 @default.
- W2001736182 countsByYear W20017361822015 @default.
- W2001736182 countsByYear W20017361822016 @default.
- W2001736182 countsByYear W20017361822017 @default.
- W2001736182 countsByYear W20017361822018 @default.
- W2001736182 countsByYear W20017361822019 @default.
- W2001736182 countsByYear W20017361822020 @default.
- W2001736182 countsByYear W20017361822021 @default.
- W2001736182 countsByYear W20017361822022 @default.
- W2001736182 countsByYear W20017361822023 @default.
- W2001736182 crossrefType "journal-article" @default.
- W2001736182 hasAuthorship W2001736182A5003678910 @default.
- W2001736182 hasAuthorship W2001736182A5024720824 @default.
- W2001736182 hasAuthorship W2001736182A5047243678 @default.
- W2001736182 hasAuthorship W2001736182A5050051706 @default.
- W2001736182 hasBestOaLocation W20017361822 @default.
- W2001736182 hasConcept C123012128 @default.
- W2001736182 hasConcept C136834591 @default.
- W2001736182 hasConcept C162746124 @default.
- W2001736182 hasConcept C169760540 @default.
- W2001736182 hasConcept C202751555 @default.
- W2001736182 hasConcept C20875687 @default.
- W2001736182 hasConcept C2777542384 @default.
- W2001736182 hasConcept C2779715522 @default.
- W2001736182 hasConcept C2780394083 @default.
- W2001736182 hasConcept C28328180 @default.
- W2001736182 hasConcept C39961270 @default.
- W2001736182 hasConcept C4746552 @default.
- W2001736182 hasConcept C502942594 @default.
- W2001736182 hasConcept C529278444 @default.
- W2001736182 hasConcept C55493867 @default.
- W2001736182 hasConcept C86803240 @default.
- W2001736182 hasConcept C95444343 @default.
- W2001736182 hasConceptScore W2001736182C123012128 @default.
- W2001736182 hasConceptScore W2001736182C136834591 @default.
- W2001736182 hasConceptScore W2001736182C162746124 @default.
- W2001736182 hasConceptScore W2001736182C169760540 @default.
- W2001736182 hasConceptScore W2001736182C202751555 @default.
- W2001736182 hasConceptScore W2001736182C20875687 @default.
- W2001736182 hasConceptScore W2001736182C2777542384 @default.