Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001750643> ?p ?o ?g. }
- W2001750643 endingPage "340" @default.
- W2001750643 startingPage "334" @default.
- W2001750643 abstract "Abstract Intracellular α‐synuclein inclusion formation in glial cells is frequently seen in Parkinson's disease and multiple system atrophy. Microglial activation in these neurodegenerative disorders suggests that neuroinflammatory responses might interact with α‐synuclein and contribute to the pathogenesis of these disorders. To study the role of tumor necrosis factor‐α (TNF‐α), an important proinflammatory cytokine produced by microglia, on cells overexpressing α‐synuclein we have used the astrocytoma cell line U373 engineered to express C‐terminally truncated α‐synuclein as a fusion protein with red or green fluorescent proteins. We demonstrate that α‐synuclein overexpression augmented TNF‐α‐induced apoptotic cell death in U373 cells by induction of caspase activation. Furthermore, TNF‐α exposure was associated with significant cytoskeletal changes characterized by altered inclusion composition with loss of cytoskeletal proteins and elevation of high‐molecular‐weight α‐synuclein species. We conclude that α‐synuclein overexpression significantly increases the vulnerability of U373 cells to apoptosis through TNF‐α‐mediated pathways. © 2003 Wiley‐Liss, Inc." @default.
- W2001750643 created "2016-06-24" @default.
- W2001750643 creator A5043082016 @default.
- W2001750643 creator A5060641186 @default.
- W2001750643 creator A5061678972 @default.
- W2001750643 creator A5064715109 @default.
- W2001750643 creator A5075442778 @default.
- W2001750643 creator A5085792808 @default.
- W2001750643 date "2003-06-18" @default.
- W2001750643 modified "2023-10-15" @default.
- W2001750643 title "Tumor necrosis factor-?-induced cell death in U373 cells overexpressing ?-synuclein" @default.
- W2001750643 cites W1489341550 @default.
- W2001750643 cites W1518893426 @default.
- W2001750643 cites W1530609782 @default.
- W2001750643 cites W1557235501 @default.
- W2001750643 cites W1577637371 @default.
- W2001750643 cites W1637321639 @default.
- W2001750643 cites W1978989017 @default.
- W2001750643 cites W1979605279 @default.
- W2001750643 cites W1982177950 @default.
- W2001750643 cites W1989149919 @default.
- W2001750643 cites W2004315433 @default.
- W2001750643 cites W2008748100 @default.
- W2001750643 cites W2013085111 @default.
- W2001750643 cites W2030748454 @default.
- W2001750643 cites W2033402586 @default.
- W2001750643 cites W2040096338 @default.
- W2001750643 cites W2045113959 @default.
- W2001750643 cites W2047752929 @default.
- W2001750643 cites W2049104084 @default.
- W2001750643 cites W2061497413 @default.
- W2001750643 cites W2066777532 @default.
- W2001750643 cites W2068595118 @default.
- W2001750643 cites W2074649216 @default.
- W2001750643 cites W2078056296 @default.
- W2001750643 cites W2093012444 @default.
- W2001750643 cites W2093388612 @default.
- W2001750643 cites W2104912043 @default.
- W2001750643 cites W2107434243 @default.
- W2001750643 cites W2107451956 @default.
- W2001750643 cites W2110495699 @default.
- W2001750643 cites W2116393840 @default.
- W2001750643 cites W2137829901 @default.
- W2001750643 cites W2165710243 @default.
- W2001750643 cites W2168363780 @default.
- W2001750643 cites W2314185656 @default.
- W2001750643 cites W4294309387 @default.
- W2001750643 cites W4295689620 @default.
- W2001750643 cites W4297407199 @default.
- W2001750643 doi "https://doi.org/10.1002/jnr.10662" @default.
- W2001750643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12868067" @default.
- W2001750643 hasPublicationYear "2003" @default.
- W2001750643 type Work @default.
- W2001750643 sameAs 2001750643 @default.
- W2001750643 citedByCount "36" @default.
- W2001750643 countsByYear W20017506432012 @default.
- W2001750643 countsByYear W20017506432013 @default.
- W2001750643 countsByYear W20017506432015 @default.
- W2001750643 countsByYear W20017506432016 @default.
- W2001750643 countsByYear W20017506432017 @default.
- W2001750643 countsByYear W20017506432018 @default.
- W2001750643 countsByYear W20017506432019 @default.
- W2001750643 countsByYear W20017506432020 @default.
- W2001750643 countsByYear W20017506432021 @default.
- W2001750643 countsByYear W20017506432022 @default.
- W2001750643 countsByYear W20017506432023 @default.
- W2001750643 crossrefType "journal-article" @default.
- W2001750643 hasAuthorship W2001750643A5043082016 @default.
- W2001750643 hasAuthorship W2001750643A5060641186 @default.
- W2001750643 hasAuthorship W2001750643A5061678972 @default.
- W2001750643 hasAuthorship W2001750643A5064715109 @default.
- W2001750643 hasAuthorship W2001750643A5075442778 @default.
- W2001750643 hasAuthorship W2001750643A5085792808 @default.
- W2001750643 hasConcept C142724271 @default.
- W2001750643 hasConcept C164027704 @default.
- W2001750643 hasConcept C17991360 @default.
- W2001750643 hasConcept C190283241 @default.
- W2001750643 hasConcept C203014093 @default.
- W2001750643 hasConcept C2776914184 @default.
- W2001750643 hasConcept C2776925932 @default.
- W2001750643 hasConcept C2777916540 @default.
- W2001750643 hasConcept C2779134260 @default.
- W2001750643 hasConcept C2779734285 @default.
- W2001750643 hasConcept C2779830541 @default.
- W2001750643 hasConcept C2781449126 @default.
- W2001750643 hasConcept C31573885 @default.
- W2001750643 hasConcept C502942594 @default.
- W2001750643 hasConcept C503630168 @default.
- W2001750643 hasConcept C54355233 @default.
- W2001750643 hasConcept C71924100 @default.
- W2001750643 hasConcept C86803240 @default.
- W2001750643 hasConcept C87753298 @default.
- W2001750643 hasConcept C95444343 @default.
- W2001750643 hasConceptScore W2001750643C142724271 @default.
- W2001750643 hasConceptScore W2001750643C164027704 @default.
- W2001750643 hasConceptScore W2001750643C17991360 @default.
- W2001750643 hasConceptScore W2001750643C190283241 @default.
- W2001750643 hasConceptScore W2001750643C203014093 @default.