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- W2001759171 abstract "Abstract Isoprenaline, isoetharine, salbutamol, WG 253 and WG 284, which are predominantly β-adrenoceptor stimulants, were compared on isolated spiral preparations of human saphenous vein. While isoprenaline, WG 253 and salbutamol contracted the preparations, in concentrations up to 600 μg/ml, isoetharine and WG 284 did not do so. β-Adrenoceptor blockade with propranolol did not reduce the contractions produced by these compounds. α-Adrenoceptor blockade with thymoxamine abolished the contractions produced by isoprenaline and WG 253, but not the small contraction produced by salbutamol. There appeared to be no correlation between the selectivity to β1- and β2-adrenoceptors, and α-adrenoceptor activity. The mean relative potency of WG 253 with respect to isoprenaline (=1) was 0.80." @default.
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- W2001759171 date "1971-10-01" @default.
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- W2001759171 title "The relative potency of some β-adrenoceptor agonist on isolated human vein" @default.
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- W2001759171 doi "https://doi.org/10.1016/0014-2999(71)90002-1" @default.
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