FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001762419> ?p ?o ?g. }

• W2001762419 endingPage "790" @default.
• W2001762419 startingPage "780" @default.
• W2001762419 abstract "Abstract The surface nitrile groups of solvent‐cast polyacrylonitrile‐ co ‐vinyl chloride (PAN‐VC) films were converted into amidine groups through a two‐step process analogous to Pinner's method of 1877. The amidine groups were hypothesized to reduce platelet adhesion and activation through the inhibition of the classical complement pathway, as was noted for benzamidine and pentamidine in earlier studies. A slightly higher nitrogen content was detected on the amidine‐surface modified (ASM) samples by X‐ray photoelectron spectroscopy relative to the solvent‐treated and unmodified controls. Reaction with pentafluoroaldehyde resulted in increased fluorine and decreased nitrogen contents (relative), consistent with the formation of a Schiff base with the primary nitrogen of the amidine on ASM PAN‐VC surface. The corresponding yield was 17.2% based on nitrile groups and 9.6% based on all repeating units of the base polymer. Despite this low degree of amidine modification, platelet adhesion was ∼40% lower on the amidine‐modified film compared to the solvent‐treated and unmodified controls. The scanning electron micrographs also showed less activation in the adherent platelets. A small reduction in C1s binding was also noted on the amidine‐modified surface. Taken together, these results support the notion that amidine modification may be a useful approach to improve the nonthrombogenicity of a biomaterial. However, much effort is required to improve the degree of surface modification and to provide unequivocal evidence linking amidines to the improved thrombogenicity. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009" @default.
• W2001762419 created "2016-06-24" @default.
• W2001762419 creator A5028067662 @default.
• W2001762419 creator A5080324706 @default.
• W2001762419 date "2008-05-08" @default.
• W2001762419 modified "2023-10-18" @default.
• W2001762419 title "Amidine surface modification of poly(acrylonitrile-<i>co</i>-vinyl chloride) reduces platelet adhesion" @default.
• W2001762419 cites W135339175 @default.
• W2001762419 cites W1493824599 @default.
• W2001762419 cites W1508096166 @default.
• W2001762419 cites W1535022005 @default.
• W2001762419 cites W1758130036 @default.
• W2001762419 cites W183757317 @default.
• W2001762419 cites W1960376801 @default.
• W2001762419 cites W1994541790 @default.
• W2001762419 cites W2006621357 @default.
• W2001762419 cites W2007280066 @default.
• W2001762419 cites W2008139210 @default.
• W2001762419 cites W2014338575 @default.
• W2001762419 cites W2016531677 @default.
• W2001762419 cites W2021623392 @default.
• W2001762419 cites W2027294313 @default.
• W2001762419 cites W2031551708 @default.
• W2001762419 cites W2039205501 @default.
• W2001762419 cites W2043523242 @default.
• W2001762419 cites W2054533404 @default.
• W2001762419 cites W2066686392 @default.
• W2001762419 cites W2074175352 @default.
• W2001762419 cites W2076585856 @default.
• W2001762419 cites W2081713390 @default.
• W2001762419 cites W2082388138 @default.
• W2001762419 cites W2092114133 @default.
• W2001762419 cites W2142955857 @default.
• W2001762419 cites W2152750692 @default.
• W2001762419 cites W2291348653 @default.
• W2001762419 cites W2396894070 @default.
• W2001762419 cites W2406235286 @default.
• W2001762419 cites W2408815987 @default.
• W2001762419 cites W4237734963 @default.
• W2001762419 cites W4253525464 @default.
• W2001762419 cites W77107658 @default.
• W2001762419 doi "https://doi.org/10.1002/jbm.a.32022" @default.
• W2001762419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18465816" @default.
• W2001762419 hasPublicationYear "2008" @default.
• W2001762419 type Work @default.
• W2001762419 sameAs 2001762419 @default.
• W2001762419 citedByCount "9" @default.
• W2001762419 countsByYear W20017624192012 @default.
• W2001762419 countsByYear W20017624192013 @default.
• W2001762419 countsByYear W20017624192019 @default.
• W2001762419 countsByYear W20017624192020 @default.
• W2001762419 crossrefType "journal-article" @default.
• W2001762419 hasAuthorship W2001762419A5028067662 @default.
• W2001762419 hasAuthorship W2001762419A5080324706 @default.
• W2001762419 hasConcept C115537861 @default.
• W2001762419 hasConcept C13965031 @default.
• W2001762419 hasConcept C147789679 @default.
• W2001762419 hasConcept C15920480 @default.
• W2001762419 hasConcept C159985019 @default.
• W2001762419 hasConcept C178790620 @default.
• W2001762419 hasConcept C181199279 @default.
• W2001762419 hasConcept C184133267 @default.
• W2001762419 hasConcept C185592680 @default.
• W2001762419 hasConcept C188027245 @default.
• W2001762419 hasConcept C192562407 @default.
• W2001762419 hasConcept C2778372188 @default.
• W2001762419 hasConcept C2778622868 @default.
• W2001762419 hasConcept C2779240715 @default.
• W2001762419 hasConcept C2779288520 @default.
• W2001762419 hasConcept C521977710 @default.
• W2001762419 hasConcept C84416704 @default.
• W2001762419 hasConceptScore W2001762419C115537861 @default.
• W2001762419 hasConceptScore W2001762419C13965031 @default.
• W2001762419 hasConceptScore W2001762419C147789679 @default.
• W2001762419 hasConceptScore W2001762419C15920480 @default.
• W2001762419 hasConceptScore W2001762419C159985019 @default.
• W2001762419 hasConceptScore W2001762419C178790620 @default.
• W2001762419 hasConceptScore W2001762419C181199279 @default.
• W2001762419 hasConceptScore W2001762419C184133267 @default.
• W2001762419 hasConceptScore W2001762419C185592680 @default.
• W2001762419 hasConceptScore W2001762419C188027245 @default.
• W2001762419 hasConceptScore W2001762419C192562407 @default.
• W2001762419 hasConceptScore W2001762419C2778372188 @default.
• W2001762419 hasConceptScore W2001762419C2778622868 @default.
• W2001762419 hasConceptScore W2001762419C2779240715 @default.
• W2001762419 hasConceptScore W2001762419C2779288520 @default.
• W2001762419 hasConceptScore W2001762419C521977710 @default.
• W2001762419 hasConceptScore W2001762419C84416704 @default.
• W2001762419 hasIssue "3" @default.
• W2001762419 hasLocation W20017624191 @default.
• W2001762419 hasLocation W20017624192 @default.
• W2001762419 hasOpenAccess W2001762419 @default.
• W2001762419 hasPrimaryLocation W20017624191 @default.
• W2001762419 hasRelatedWork W1561903353 @default.
• W2001762419 hasRelatedWork W1996074742 @default.
• W2001762419 hasRelatedWork W2012622272 @default.
• W2001762419 hasRelatedWork W2029910931 @default.
• W2001762419 hasRelatedWork W2047504478 @default.

• next