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- W2001766950 abstract "Uric acid (UA) is known to play an important role as an endogenous antioxidant. However, its insolubility in the serum is a risk for hyperuricemia. We assume that UA is an equivalent to hydroquinone or p-aminophenol, which can be oxidized to quinone/quinoimine and thus acts as a radical scavenger. Based on this hypothesis, a series of UA analogs was designed and synthesized. In the chemical radical scavenging assay, active compounds were considered as hydroquinone or p-aminophenol equivalents. A highly functionalized UA structure is not essential to have radical scavenging activity. Potent active 5-hydroxyindolinones (1a, 2a, and 3a) showed sufficient activity with high solubility and low cytotoxicity." @default.
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- W2001766950 date "2013-01-01" @default.
- W2001766950 modified "2023-10-11" @default.
- W2001766950 title "Synthesis, radical scavenging activity and structure–activity relationship of uric acid analogs" @default.
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- W2001766950 doi "https://doi.org/10.1039/c2md20287e" @default.
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