FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001775655> ?p ?o ?g. }

• W2001775655 endingPage "946" @default.
• W2001775655 startingPage "939" @default.
• W2001775655 abstract "Osteoarthritis (OA) is a major cause of pain and disability in the US. A problem with early intervention is that it is very difficult to detect OA before irreversible damage has already occurred. This study characterizes a novel method of early OA detection in a mouse model of post-traumatic osteoarthritis (PTOA) using fluorescent nanosomes. In this investigation, knee injury was induced in mice by compressive loading. Nanosomes encapsulating fluorescent dye and conjugated to collagen type II antibody were utilized to detect cartilage damage in vivo. Cartilage damage and OA progression were detected by the use of fluorescence-imaging (IVIS) and histopathology. Histopathology analyses showed that mild osteoarthritic changes had occurred. This corresponded with a higher fluorescence on IVIS imaging due to more nanosome binding. These results suggest that theragnostic nanosomes may be useful for detection of early PTOA as well as for targeted delivery of interventional agents. With the aging population, osteoarthritis now poses a significant problem worldwide. Early detection may help slow the progression of the disease. In this study, the authors described the use of fluorescent nanosomes to detect early cartilage damage in a mouse model of osteoarthritis. This detection method may also prove to be useful for targeted delivery of drugs in the future." @default.
• W2001775655 created "2016-06-24" @default.
• W2001775655 creator A5014869638 @default.
• W2001775655 creator A5023635229 @default.
• W2001775655 creator A5039556389 @default.
• W2001775655 creator A5044927118 @default.
• W2001775655 creator A5052448075 @default.
• W2001775655 date "2015-05-01" @default.
• W2001775655 modified "2023-09-27" @default.
• W2001775655 title "Detection of early cartilage damage using targeted nanosomes in a post-traumatic osteoarthritis mouse model" @default.
• W2001775655 cites W118851396 @default.
• W2001775655 cites W150096201 @default.
• W2001775655 cites W1551310212 @default.
• W2001775655 cites W1801949341 @default.
• W2001775655 cites W1904364980 @default.
• W2001775655 cites W1913625561 @default.
• W2001775655 cites W1969830786 @default.
• W2001775655 cites W1982167517 @default.
• W2001775655 cites W1985842679 @default.
• W2001775655 cites W1986129921 @default.
• W2001775655 cites W1989856361 @default.
• W2001775655 cites W2002251686 @default.
• W2001775655 cites W2002931693 @default.
• W2001775655 cites W2003867975 @default.
• W2001775655 cites W2004488501 @default.
• W2001775655 cites W2018647053 @default.
• W2001775655 cites W2028920679 @default.
• W2001775655 cites W2039577930 @default.
• W2001775655 cites W2047473852 @default.
• W2001775655 cites W2048759561 @default.
• W2001775655 cites W2054729774 @default.
• W2001775655 cites W2065587003 @default.
• W2001775655 cites W2092423460 @default.
• W2001775655 cites W2094487294 @default.
• W2001775655 cites W2101197534 @default.
• W2001775655 cites W2102308673 @default.
• W2001775655 cites W2105603468 @default.
• W2001775655 cites W2109971798 @default.
• W2001775655 cites W2118963985 @default.
• W2001775655 cites W2128088040 @default.
• W2001775655 cites W2135616992 @default.
• W2001775655 cites W2136038462 @default.
• W2001775655 cites W2167037356 @default.
• W2001775655 cites W2334545857 @default.
• W2001775655 cites W4232024554 @default.
• W2001775655 doi "https://doi.org/10.1016/j.nano.2015.01.011" @default.
• W2001775655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25680539" @default.
• W2001775655 hasPublicationYear "2015" @default.
• W2001775655 type Work @default.
• W2001775655 sameAs 2001775655 @default.
• W2001775655 citedByCount "44" @default.
• W2001775655 countsByYear W20017756552015 @default.
• W2001775655 countsByYear W20017756552016 @default.
• W2001775655 countsByYear W20017756552017 @default.
• W2001775655 countsByYear W20017756552018 @default.
• W2001775655 countsByYear W20017756552019 @default.
• W2001775655 countsByYear W20017756552020 @default.
• W2001775655 countsByYear W20017756552021 @default.
• W2001775655 countsByYear W20017756552022 @default.
• W2001775655 countsByYear W20017756552023 @default.
• W2001775655 crossrefType "journal-article" @default.
• W2001775655 hasAuthorship W2001775655A5014869638 @default.
• W2001775655 hasAuthorship W2001775655A5023635229 @default.
• W2001775655 hasAuthorship W2001775655A5039556389 @default.
• W2001775655 hasAuthorship W2001775655A5044927118 @default.
• W2001775655 hasAuthorship W2001775655A5052448075 @default.
• W2001775655 hasConcept C105702510 @default.
• W2001775655 hasConcept C142724271 @default.
• W2001775655 hasConcept C150903083 @default.
• W2001775655 hasConcept C204787440 @default.
• W2001775655 hasConcept C207001950 @default.
• W2001775655 hasConcept C2776164576 @default.
• W2001775655 hasConcept C2780550940 @default.
• W2001775655 hasConcept C2908647359 @default.
• W2001775655 hasConcept C2909674901 @default.
• W2001775655 hasConcept C3020332539 @default.
• W2001775655 hasConcept C544855455 @default.
• W2001775655 hasConcept C71924100 @default.
• W2001775655 hasConcept C86803240 @default.
• W2001775655 hasConcept C99454951 @default.
• W2001775655 hasConceptScore W2001775655C105702510 @default.
• W2001775655 hasConceptScore W2001775655C142724271 @default.
• W2001775655 hasConceptScore W2001775655C150903083 @default.
• W2001775655 hasConceptScore W2001775655C204787440 @default.
• W2001775655 hasConceptScore W2001775655C207001950 @default.
• W2001775655 hasConceptScore W2001775655C2776164576 @default.
• W2001775655 hasConceptScore W2001775655C2780550940 @default.
• W2001775655 hasConceptScore W2001775655C2908647359 @default.
• W2001775655 hasConceptScore W2001775655C2909674901 @default.
• W2001775655 hasConceptScore W2001775655C3020332539 @default.
• W2001775655 hasConceptScore W2001775655C544855455 @default.
• W2001775655 hasConceptScore W2001775655C71924100 @default.
• W2001775655 hasConceptScore W2001775655C86803240 @default.
• W2001775655 hasConceptScore W2001775655C99454951 @default.
• W2001775655 hasIssue "4" @default.
• W2001775655 hasLocation W20017756551 @default.
• W2001775655 hasLocation W20017756552 @default.
• W2001775655 hasOpenAccess W2001775655 @default.

• next