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- W2001786333 abstract "99m Tc-labeled N -[2,6-dimethylphenylcarbamoylmethyl]iminodiacetic acid ( 99m Tc-HIDA) underwent an acid catalyzed ligand exchange reaction in the presence of EDTA with half-lives of 2.5, 11, and 72 hr at pH values of 2.9, 4.4, and 6.4, respectively. The half-life for dissociation of 99m Tc-HIDA in the presence of EDTA at pH 4.4 was found to be substantially independent of EDTA concentration. In addition, the formation constant for 99m Tc-EDTA prepared by stannous ion reduction is 300 times larger than the overall formation constant for 99m Tc-HIDA. This work indicates that 99m Tc-(HIDA) 2 exists as an anionic bis compound and that the bond between reduced technetium and N -substituted iminodiacetic acids should remain intact for long periods of time at physiologic pH and temperature." @default.
- W2001786333 created "2016-06-24" @default.
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- W2001786333 date "1977-08-01" @default.
- W2001786333 modified "2023-09-25" @default.
- W2001786333 title "Stability of 99mTc-labeled N-substituted iminodiacetic acids: Ligand exchange reaction between 99mTc-HIDA and EDTA" @default.
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- W2001786333 doi "https://doi.org/10.1016/0020-708x(77)90086-2" @default.
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