FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001791567> ?p ?o ?g. }

• W2001791567 endingPage "1046" @default.
• W2001791567 startingPage "1038" @default.
• W2001791567 abstract "Abstract Retinoids are natural and synthetic derivatives of vitamin A that have great promise for cancer therapy and chemoprevention. Of the retinoids developed so far, 4‐(N‐hydroxyphenyl)retinamide (4‐HPR or fenretinide) appears to have the best therapeutic potential in vitro and in vivo and is currently being tested in clinical trials for cancer prevention and therapy. To develop other potentially potent antitumor agents, we synthesized 85 retinoid derivatives. In an initial screening of these synthetic retinoids using the HCT116 colon cancer cell line, we found that 4‐amino‐2‐(butyrylamino)phenyl(2E,4E,6E,8E)‐3,7‐dimethyl‐9‐(2,6,6‐trimethyl‐1‐cyclohexenyl)‐2,4,6,8‐nonatetraenoate (ABPN or CBG41) induced the greatest growth inhibition, with an IC 50 value of 0.6 μM. Subsequent studies in other cancer cell lines indicated that ABPN was much more growth‐inhibitory than all‐ trans retinoic acid or 4‐HPR. Compared to 4‐HPR, ABPN induced 5.5‐ to 70.0‐fold more growth inhibition in most cancer cells, with the exception of gynecologic cancer cells. In these cells, the antiproliferative effect was only 1.5‐ to 2.8‐fold more than 4‐HPR. We examined the molecular mechanism underlying the difference in growth inhibition between 4‐HPR and ABPN. DAPI staining, DNA fragmentation, FACS and Western blotting analyses suggest that ABPN induced apoptosis by activating caspase‐3 and ‐8, which may result in increased PARP cleavage. Unlike 4‐HPR, ABPN activated all 3 RAR isotypes to an extent similar to AtRA. In addition, ABPN significantly inhibited AP‐1 transcriptional activity and thus greatly suppressed the expression of the matrix metalloproteinase ‐1, ‐2 and ‐3 genes, which are involved in tumor invasion. These results suggest that ABPN may be a promising retinoid derivative offering not only enhanced cytotoxicity, but also increased inhibition of tumor invasiveness. © 2003 Wiley‐Liss, Inc." @default.
• W2001791567 created "2016-06-24" @default.
• W2001791567 creator A5000233517 @default.
• W2001791567 creator A5002864551 @default.
• W2001791567 creator A5027936925 @default.
• W2001791567 creator A5055660175 @default.
• W2001791567 creator A5063335685 @default.
• W2001791567 creator A5073480785 @default.
• W2001791567 creator A5085160935 @default.
• W2001791567 date "2003-09-12" @default.
• W2001791567 modified "2023-10-17" @default.
• W2001791567 title "Novel retinoic acid derivative ABPN has potent inhibitory activity on cell growth and apoptosis in cancer cells" @default.
• W2001791567 cites W1595664534 @default.
• W2001791567 cites W1800142641 @default.
• W2001791567 cites W1925078242 @default.
• W2001791567 cites W1927684145 @default.
• W2001791567 cites W1944595096 @default.
• W2001791567 cites W1946907325 @default.
• W2001791567 cites W1948079440 @default.
• W2001791567 cites W1964224609 @default.
• W2001791567 cites W1967004332 @default.
• W2001791567 cites W1971624992 @default.
• W2001791567 cites W1980047699 @default.
• W2001791567 cites W1994994559 @default.
• W2001791567 cites W1995133050 @default.
• W2001791567 cites W2001972438 @default.
• W2001791567 cites W2011157209 @default.
• W2001791567 cites W2011184703 @default.
• W2001791567 cites W2011257870 @default.
• W2001791567 cites W2036224418 @default.
• W2001791567 cites W2037075039 @default.
• W2001791567 cites W2040468663 @default.
• W2001791567 cites W2062445186 @default.
• W2001791567 cites W2062465964 @default.
• W2001791567 cites W2063668355 @default.
• W2001791567 cites W2070526601 @default.
• W2001791567 cites W2071200701 @default.
• W2001791567 cites W2071952704 @default.
• W2001791567 cites W2083764883 @default.
• W2001791567 cites W2085901559 @default.
• W2001791567 cites W2087287360 @default.
• W2001791567 cites W2089461613 @default.
• W2001791567 cites W2098860085 @default.
• W2001791567 cites W2100321375 @default.
• W2001791567 cites W2110795525 @default.
• W2001791567 cites W2123747845 @default.
• W2001791567 cites W2139694919 @default.
• W2001791567 cites W2143241514 @default.
• W2001791567 cites W2149422028 @default.
• W2001791567 cites W2152153239 @default.
• W2001791567 cites W2152653242 @default.
• W2001791567 cites W2254093732 @default.
• W2001791567 cites W2318410985 @default.
• W2001791567 cites W2318774698 @default.
• W2001791567 cites W2321951461 @default.
• W2001791567 cites W2406258157 @default.
• W2001791567 doi "https://doi.org/10.1002/ijc.11489" @default.
• W2001791567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14601067" @default.
• W2001791567 hasPublicationYear "2003" @default.
• W2001791567 type Work @default.
• W2001791567 sameAs 2001791567 @default.
• W2001791567 citedByCount "20" @default.
• W2001791567 countsByYear W20017915672015 @default.
• W2001791567 countsByYear W20017915672017 @default.
• W2001791567 countsByYear W20017915672019 @default.
• W2001791567 countsByYear W20017915672021 @default.
• W2001791567 countsByYear W20017915672022 @default.
• W2001791567 crossrefType "journal-article" @default.
• W2001791567 hasAuthorship W2001791567A5000233517 @default.
• W2001791567 hasAuthorship W2001791567A5002864551 @default.
• W2001791567 hasAuthorship W2001791567A5027936925 @default.
• W2001791567 hasAuthorship W2001791567A5055660175 @default.
• W2001791567 hasAuthorship W2001791567A5063335685 @default.
• W2001791567 hasAuthorship W2001791567A5073480785 @default.
• W2001791567 hasAuthorship W2001791567A5085160935 @default.
• W2001791567 hasBestOaLocation W20017915671 @default.
• W2001791567 hasConcept C121608353 @default.
• W2001791567 hasConcept C126322002 @default.
• W2001791567 hasConcept C190283241 @default.
• W2001791567 hasConcept C2775954498 @default.
• W2001791567 hasConcept C2779963572 @default.
• W2001791567 hasConcept C2780533455 @default.
• W2001791567 hasConcept C2781121885 @default.
• W2001791567 hasConcept C502942594 @default.
• W2001791567 hasConcept C54355233 @default.
• W2001791567 hasConcept C55493867 @default.
• W2001791567 hasConcept C71924100 @default.
• W2001791567 hasConcept C81885089 @default.
• W2001791567 hasConcept C86803240 @default.
• W2001791567 hasConcept C96232424 @default.
• W2001791567 hasConcept C98274493 @default.
• W2001791567 hasConceptScore W2001791567C121608353 @default.
• W2001791567 hasConceptScore W2001791567C126322002 @default.
• W2001791567 hasConceptScore W2001791567C190283241 @default.
• W2001791567 hasConceptScore W2001791567C2775954498 @default.
• W2001791567 hasConceptScore W2001791567C2779963572 @default.
• W2001791567 hasConceptScore W2001791567C2780533455 @default.
• W2001791567 hasConceptScore W2001791567C2781121885 @default.

• next