Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001792249> ?p ?o ?g. }
- W2001792249 endingPage "36" @default.
- W2001792249 startingPage "30" @default.
- W2001792249 abstract "8-Methoxypsoralen+UVA (ultraviolet light of 320-400 nm) known as PUVA has been in use for a number of years for the treatment of psoriasis and vitiligo. The treatment possibly works on the basis of UVA photoactivated 8-methoxypsoralen binding to DNA forming both single strand and double strand type damage. We have used Escherichia coli as model system in studying PUVA induced DNA damage and repair. It has been known for some time that the photoactivated 8-methoxypsoralen, besides intercalating with DNA, generates at least two reactive oxygen species (ROS): hydroxyl radicals and superoxide anions, and also singlet oxygen. In this study it has been found that, in E. coli, malate dehydrogenase, succinate dehydrogenase and NADH:ubiquinone oxidoreductase can protect cells from PUVA killing presumably by scavenging these ROS. Possible mechanisms have been proposed for these enzymes as cell protectors. Studies also suggest the potential for the use of PUVA in the treatment of a large number of human diseases. This study also finds that, unlike 8-methoxypsoralen, trioxsalen (4,5',8-trimethylpsoralen, another derivative of psoralens) does not generate ROS by UVA photoactivation; and hence the mode of action of trioxsalen and PUVA overlaps only in the binding of these molecules to DNA in the presence of UVA." @default.
- W2001792249 created "2016-06-24" @default.
- W2001792249 creator A5003662404 @default.
- W2001792249 creator A5019536560 @default.
- W2001792249 creator A5031960613 @default.
- W2001792249 date "2012-11-01" @default.
- W2001792249 modified "2023-10-18" @default.
- W2001792249 title "Identification of new scavengers for hydroxyl radicals and superoxide dismutase by utilising ultraviolet A photoreaction of 8-methoxypsoralen and a variety of mutants of Escherichia coli: Implications on certain diseases of DNA repair deficiency" @default.
- W2001792249 cites W1891843126 @default.
- W2001792249 cites W1963515474 @default.
- W2001792249 cites W1966655178 @default.
- W2001792249 cites W1967533882 @default.
- W2001792249 cites W1968965523 @default.
- W2001792249 cites W1969437676 @default.
- W2001792249 cites W1974165972 @default.
- W2001792249 cites W1974425878 @default.
- W2001792249 cites W1975980865 @default.
- W2001792249 cites W1985432948 @default.
- W2001792249 cites W1997341514 @default.
- W2001792249 cites W2005946676 @default.
- W2001792249 cites W2006117726 @default.
- W2001792249 cites W2014199526 @default.
- W2001792249 cites W2018353938 @default.
- W2001792249 cites W2020999136 @default.
- W2001792249 cites W2023955250 @default.
- W2001792249 cites W2039018479 @default.
- W2001792249 cites W2050522578 @default.
- W2001792249 cites W2052011258 @default.
- W2001792249 cites W2054014714 @default.
- W2001792249 cites W2054904406 @default.
- W2001792249 cites W2058180031 @default.
- W2001792249 cites W2060792718 @default.
- W2001792249 cites W2066904721 @default.
- W2001792249 cites W2068122235 @default.
- W2001792249 cites W2075147964 @default.
- W2001792249 cites W2080602020 @default.
- W2001792249 cites W2082934471 @default.
- W2001792249 cites W2090661909 @default.
- W2001792249 cites W2090934733 @default.
- W2001792249 cites W2117813680 @default.
- W2001792249 cites W2139902189 @default.
- W2001792249 cites W2145879551 @default.
- W2001792249 cites W2152420555 @default.
- W2001792249 cites W2170406937 @default.
- W2001792249 cites W2284946088 @default.
- W2001792249 doi "https://doi.org/10.1016/j.jphotobiol.2012.07.004" @default.
- W2001792249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22940499" @default.
- W2001792249 hasPublicationYear "2012" @default.
- W2001792249 type Work @default.
- W2001792249 sameAs 2001792249 @default.
- W2001792249 citedByCount "11" @default.
- W2001792249 countsByYear W20017922492013 @default.
- W2001792249 countsByYear W20017922492014 @default.
- W2001792249 countsByYear W20017922492016 @default.
- W2001792249 countsByYear W20017922492017 @default.
- W2001792249 countsByYear W20017922492018 @default.
- W2001792249 countsByYear W20017922492021 @default.
- W2001792249 countsByYear W20017922492022 @default.
- W2001792249 crossrefType "journal-article" @default.
- W2001792249 hasAuthorship W2001792249A5003662404 @default.
- W2001792249 hasAuthorship W2001792249A5019536560 @default.
- W2001792249 hasAuthorship W2001792249A5031960613 @default.
- W2001792249 hasConcept C104317684 @default.
- W2001792249 hasConcept C139066938 @default.
- W2001792249 hasConcept C143425029 @default.
- W2001792249 hasConcept C181199279 @default.
- W2001792249 hasConcept C185592680 @default.
- W2001792249 hasConcept C203014093 @default.
- W2001792249 hasConcept C2775838275 @default.
- W2001792249 hasConcept C2779175014 @default.
- W2001792249 hasConcept C2780564577 @default.
- W2001792249 hasConcept C2780795997 @default.
- W2001792249 hasConcept C2987116853 @default.
- W2001792249 hasConcept C48349386 @default.
- W2001792249 hasConcept C547475151 @default.
- W2001792249 hasConcept C552990157 @default.
- W2001792249 hasConcept C55493867 @default.
- W2001792249 hasConcept C75473681 @default.
- W2001792249 hasConcept C86803240 @default.
- W2001792249 hasConceptScore W2001792249C104317684 @default.
- W2001792249 hasConceptScore W2001792249C139066938 @default.
- W2001792249 hasConceptScore W2001792249C143425029 @default.
- W2001792249 hasConceptScore W2001792249C181199279 @default.
- W2001792249 hasConceptScore W2001792249C185592680 @default.
- W2001792249 hasConceptScore W2001792249C203014093 @default.
- W2001792249 hasConceptScore W2001792249C2775838275 @default.
- W2001792249 hasConceptScore W2001792249C2779175014 @default.
- W2001792249 hasConceptScore W2001792249C2780564577 @default.
- W2001792249 hasConceptScore W2001792249C2780795997 @default.
- W2001792249 hasConceptScore W2001792249C2987116853 @default.
- W2001792249 hasConceptScore W2001792249C48349386 @default.
- W2001792249 hasConceptScore W2001792249C547475151 @default.
- W2001792249 hasConceptScore W2001792249C552990157 @default.
- W2001792249 hasConceptScore W2001792249C55493867 @default.
- W2001792249 hasConceptScore W2001792249C75473681 @default.
- W2001792249 hasConceptScore W2001792249C86803240 @default.
- W2001792249 hasLocation W20017922491 @default.
- W2001792249 hasLocation W20017922492 @default.