FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001794312> ?p ?o ?g. }

• W2001794312 endingPage "145" @default.
• W2001794312 startingPage "138" @default.
• W2001794312 abstract "Background. The most widely distributed nonreceptor tyrosine kinase is pp60c-src (src), yet the role of this intracellular signaling protein in cell migration has not been defined. Given that smooth muscle cell (SMC) migration is essential for the development of intimal hyperplasia, we investigated the importance of src in locomotion of human vascular SMC. Methods. SMC migration was evaluated using a microchemotaxis chamber assay and videomicroscopy. Src kinase activity was determined by measuring phosphorylation of a synthetic derivative of p34cdc2, a specific substrate for src. Blocking antibodies to src were introduced using a cytoplasmic microinjection technique. Results. Stimulation of SMC with platelet-derived growth factor (PDGF)-BB and AB resulted in an increase in src activation, whereas PDGF-AA did not consistently enhance src activity. These findings correlated with the ability of the PDGF isotypes to stimulate SMC chemotaxis; PDGF-BB and AB produced 7.4 ± 0.3- and 5.3 ± 0.5-fold increases in SMC chemotaxis, whereas PDGF-AA inhibited chemotaxis. SMC migration in response to PDGF-BB and serum was significantly inhibited by intracellular injection of a blocking antibody. Conclusions. Our findings reveal an association between agonist-induced src activation and chemotaxis. Moreover, an antibody that inhibits src activation dramatically inhibits migration of individual SMC. We conclude that activation of src is necessary for SMC migration. Because of its importance in SMC migration, either molecular or pharmacologic inhibitors of src may be useful in the control of intimal hyperplasia." @default.
• W2001794312 created "2016-06-24" @default.
• W2001794312 creator A5010251189 @default.
• W2001794312 creator A5012140656 @default.
• W2001794312 creator A5031460918 @default.
• W2001794312 creator A5054995149 @default.
• W2001794312 creator A5060999104 @default.
• W2001794312 date "1997-08-01" @default.
• W2001794312 modified "2023-09-25" @default.
• W2001794312 title "Activation of pp60c-src is necessary for human vascular smooth muscle cell migration" @default.
• W2001794312 cites W1493020321 @default.
• W2001794312 cites W1516555591 @default.
• W2001794312 cites W1854914172 @default.
• W2001794312 cites W1973365703 @default.
• W2001794312 cites W1976231373 @default.
• W2001794312 cites W1988626066 @default.
• W2001794312 cites W2061229454 @default.
• W2001794312 cites W2067437104 @default.
• W2001794312 cites W2070727486 @default.
• W2001794312 cites W2086098969 @default.
• W2001794312 cites W2090634323 @default.
• W2001794312 cites W2091960256 @default.
• W2001794312 cites W2101501882 @default.
• W2001794312 cites W2105356859 @default.
• W2001794312 cites W2117291465 @default.
• W2001794312 cites W2133160109 @default.
• W2001794312 cites W2137570167 @default.
• W2001794312 cites W2141649603 @default.
• W2001794312 cites W2158974373 @default.
• W2001794312 cites W4237062454 @default.
• W2001794312 doi "https://doi.org/10.1016/s0039-6060(97)90002-7" @default.
• W2001794312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9288116" @default.
• W2001794312 hasPublicationYear "1997" @default.
• W2001794312 type Work @default.
• W2001794312 sameAs 2001794312 @default.
• W2001794312 citedByCount "26" @default.
• W2001794312 countsByYear W20017943122012 @default.
• W2001794312 countsByYear W20017943122013 @default.
• W2001794312 countsByYear W20017943122014 @default.
• W2001794312 countsByYear W20017943122017 @default.
• W2001794312 crossrefType "journal-article" @default.
• W2001794312 hasAuthorship W2001794312A5010251189 @default.
• W2001794312 hasAuthorship W2001794312A5012140656 @default.
• W2001794312 hasAuthorship W2001794312A5031460918 @default.
• W2001794312 hasAuthorship W2001794312A5054995149 @default.
• W2001794312 hasAuthorship W2001794312A5060999104 @default.
• W2001794312 hasConcept C108636557 @default.
• W2001794312 hasConcept C11960822 @default.
• W2001794312 hasConcept C134018914 @default.
• W2001794312 hasConcept C137738243 @default.
• W2001794312 hasConcept C1491633281 @default.
• W2001794312 hasConcept C153911025 @default.
• W2001794312 hasConcept C170493617 @default.
• W2001794312 hasConcept C180361614 @default.
• W2001794312 hasConcept C2775960820 @default.
• W2001794312 hasConcept C2777553839 @default.
• W2001794312 hasConcept C2779395532 @default.
• W2001794312 hasConcept C2992686903 @default.
• W2001794312 hasConcept C42362537 @default.
• W2001794312 hasConcept C54166955 @default.
• W2001794312 hasConcept C55493867 @default.
• W2001794312 hasConcept C62112901 @default.
• W2001794312 hasConcept C62478195 @default.
• W2001794312 hasConcept C79879829 @default.
• W2001794312 hasConcept C86803240 @default.
• W2001794312 hasConcept C95444343 @default.
• W2001794312 hasConceptScore W2001794312C108636557 @default.
• W2001794312 hasConceptScore W2001794312C11960822 @default.
• W2001794312 hasConceptScore W2001794312C134018914 @default.
• W2001794312 hasConceptScore W2001794312C137738243 @default.
• W2001794312 hasConceptScore W2001794312C1491633281 @default.
• W2001794312 hasConceptScore W2001794312C153911025 @default.
• W2001794312 hasConceptScore W2001794312C170493617 @default.
• W2001794312 hasConceptScore W2001794312C180361614 @default.
• W2001794312 hasConceptScore W2001794312C2775960820 @default.
• W2001794312 hasConceptScore W2001794312C2777553839 @default.
• W2001794312 hasConceptScore W2001794312C2779395532 @default.
• W2001794312 hasConceptScore W2001794312C2992686903 @default.
• W2001794312 hasConceptScore W2001794312C42362537 @default.
• W2001794312 hasConceptScore W2001794312C54166955 @default.
• W2001794312 hasConceptScore W2001794312C55493867 @default.
• W2001794312 hasConceptScore W2001794312C62112901 @default.
• W2001794312 hasConceptScore W2001794312C62478195 @default.
• W2001794312 hasConceptScore W2001794312C79879829 @default.
• W2001794312 hasConceptScore W2001794312C86803240 @default.
• W2001794312 hasConceptScore W2001794312C95444343 @default.
• W2001794312 hasIssue "2" @default.
• W2001794312 hasLocation W20017943121 @default.
• W2001794312 hasLocation W20017943122 @default.
• W2001794312 hasOpenAccess W2001794312 @default.
• W2001794312 hasPrimaryLocation W20017943121 @default.
• W2001794312 hasRelatedWork W1177200553 @default.
• W2001794312 hasRelatedWork W2001794312 @default.
• W2001794312 hasRelatedWork W2005395047 @default.
• W2001794312 hasRelatedWork W2005709774 @default.
• W2001794312 hasRelatedWork W2028613968 @default.
• W2001794312 hasRelatedWork W2039620187 @default.
• W2001794312 hasRelatedWork W2102742081 @default.

• next