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- W2001794474 abstract "Amyloid-β (Aβ) accumulation in senile plaques is a hallmark of Alzheimer's disease. Interventions focused on reducing Aβ offer a promising approach to prevent or slow disease progression. Because of their phylogenetic proximity to humans, and their propensity to naturally accumulate Aβ deposits, we evaluated the safety and efficacy of immunizing old mouse lemurs with the Aβ derivative K6Aβ1-30. Sixteen lemurs ranging from 6 to 9 years of age were immunized with the K6Aβ1-30 peptide and 16 others received the alum adjuvant alone. Their immune response, cognition and histopathology were evaluated. Old immunized microcebes showed a rather low IgG titer against Aβ40 and 42 but significantly higher than in control animals. Five months after the last injection, the antibody response had returned to basal levels, with this reversibility being an important safety feature of the vaccine. There were limited improvements in cognitive function but immunized animals appeared to perform better than controls. Neuropathological analyses have shown no microhemorrhages or lymphocyte infiltration of the brains of old immunized lemurs. Both Aβ burden (intra- and extracellular deposits) and microglial immunoreactivity were decreased in immunized animals. Pathological tau staining and astrocytosis were not affected in the immunized primates, whereas these animals had an increase in normal tau within pyramidal neurons. The mouse lemur model complements existing animal models. Because of its normal endogenous Aβ levels, it is particularly useful to assess safety and efficacy of novel vaccines targeting Aβ pathology prior to human clinical trials." @default.
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- W2001794474 date "2010-07-01" @default.
- W2001794474 modified "2023-09-27" @default.
- W2001794474 title "P1-170: Aß derivative vaccination in old mouse lemur primates" @default.
- W2001794474 doi "https://doi.org/10.1016/j.jalz.2010.05.720" @default.
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