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• W2001812580 endingPage "317" @default.
• W2001812580 startingPage "297" @default.
• W2001812580 abstract "The recently discovered protein, leptin, which is secreted by fat cells in response to changes in body weight or energy, has been implicated in regulation of feed intake, energy expenditure and the neuroendocrine axis in rodents and humans. Leptin was first identified as the gene product found deficient in the obese ob/ob mouse. Administration of leptin to ob/ob mice led to improved reproduction as well as reduced feed intake and weight loss. The porcine leptin receptor has been cloned and is a member of the class 1 cytokine family of receptors. Leptin has been implicated in the regulation of immune function and the anorexia associated with disease. The leptin receptor is localized in the brain and pituitary of the pig. The leptin response to acute inflammation is uncoupled from anorexia and is differentially regulated among swine genotypes. In vitro studies demonstrated that the leptin gene is expressed by porcine preadipocytes and leptin gene expression is highly dependent on dexamethasone induced preadipocyte differentiation. Hormonally driven preadipocyte recruitment and subsequent fat cell size may regulate leptin gene expression in the pig. Expression of CCAAT-enhancer binding proteinalpha (C/EBPalpha) mediates insulin dependent preadipocyte leptin gene expression during lipid accretion. In contrast, insulin independent leptin gene expression may be maintained by C/EBPalpha auto-activation and phosphorylation/dephosphorylation. Adipogenic hormones may increase adipose tissue leptin gene expression in the fetus indirectly by inducing preadipocyte recruitment and subsequent differentiation. Central administration of leptin to pigs suppressed feed intake and stimulated growth hormone (GH) secretion. Serum leptin concentrations increased with age and estradiol-induced leptin mRNA expression in fat was age and weight dependent in prepuberal gilts. This occurred at the time of expected puberty in intact contemporaries and was associated with greater LH secretion. Further work demonstrated that leptin acts directly on pituitary cells to enhance LH and GH secretion, and brain tissue to stimulate gonadotropin releasing hormone secretion. Thus, development of nutritional schemes and (or) gene therapy to manipulate leptin secretion will lead to practical methods of controlling appetite, growth and reproduction in farm animals, thereby increasing efficiency of lean meat production." @default.
• W2001812580 created "2016-06-24" @default.
• W2001812580 creator A5000505037 @default.
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• W2001812580 date "2001-11-01" @default.
• W2001812580 modified "2023-10-16" @default.
• W2001812580 title "Biology of leptin in the pig" @default.
• W2001812580 cites W1502152603 @default.
• W2001812580 cites W1590709474 @default.
• W2001812580 cites W1639930240 @default.
• W2001812580 cites W1909565779 @default.
• W2001812580 cites W191006125 @default.
• W2001812580 cites W1969426803 @default.
• W2001812580 cites W1970828538 @default.
• W2001812580 cites W1971794192 @default.
• W2001812580 cites W1972356362 @default.
• W2001812580 cites W1972936284 @default.
• W2001812580 cites W1980262283 @default.
• W2001812580 cites W1981118821 @default.
• W2001812580 cites W1984028801 @default.
• W2001812580 cites W1986968528 @default.
• W2001812580 cites W1987702231 @default.
• W2001812580 cites W1987806076 @default.
• W2001812580 cites W1992206443 @default.
• W2001812580 cites W1993203791 @default.
• W2001812580 cites W1996713062 @default.
• W2001812580 cites W1999074010 @default.
• W2001812580 cites W2001163326 @default.
• W2001812580 cites W2007867899 @default.
• W2001812580 cites W2009968514 @default.
• W2001812580 cites W2013426794 @default.
• W2001812580 cites W2013583119 @default.
• W2001812580 cites W2014163208 @default.
• W2001812580 cites W2020971663 @default.
• W2001812580 cites W2021257226 @default.
• W2001812580 cites W2021725988 @default.
• W2001812580 cites W2024308134 @default.
• W2001812580 cites W2025846514 @default.
• W2001812580 cites W2032415369 @default.
• W2001812580 cites W2037816029 @default.
• W2001812580 cites W2037879329 @default.
• W2001812580 cites W2039347019 @default.
• W2001812580 cites W2041872947 @default.
• W2001812580 cites W2043673064 @default.
• W2001812580 cites W2047262272 @default.
• W2001812580 cites W2050600771 @default.
• W2001812580 cites W2051523199 @default.
• W2001812580 cites W2052175944 @default.
• W2001812580 cites W2059669578 @default.
• W2001812580 cites W2060313221 @default.
• W2001812580 cites W2060682066 @default.
• W2001812580 cites W2061046384 @default.
• W2001812580 cites W2062892263 @default.
• W2001812580 cites W2063694015 @default.
• W2001812580 cites W2063840236 @default.
• W2001812580 cites W2066231167 @default.
• W2001812580 cites W2071589836 @default.
• W2001812580 cites W2073590491 @default.
• W2001812580 cites W2073828263 @default.
• W2001812580 cites W2075019242 @default.
• W2001812580 cites W2075767463 @default.
• W2001812580 cites W2078745862 @default.
• W2001812580 cites W2080165206 @default.
• W2001812580 cites W2087390102 @default.
• W2001812580 cites W2087824154 @default.
• W2001812580 cites W2088666203 @default.
• W2001812580 cites W2089197498 @default.
• W2001812580 cites W2091087465 @default.
• W2001812580 cites W2094989225 @default.
• W2001812580 cites W2095245001 @default.
• W2001812580 cites W2100081913 @default.
• W2001812580 cites W2100951135 @default.
• W2001812580 cites W2101340193 @default.
• W2001812580 cites W2109421395 @default.
• W2001812580 cites W2121590326 @default.
• W2001812580 cites W2125312207 @default.
• W2001812580 cites W2130897100 @default.
• W2001812580 cites W2132494258 @default.
• W2001812580 cites W2137736712 @default.
• W2001812580 cites W2140228045 @default.
• W2001812580 cites W2145354869 @default.
• W2001812580 cites W2151321367 @default.
• W2001812580 cites W2156424672 @default.
• W2001812580 cites W2161584937 @default.
• W2001812580 cites W2161944247 @default.
• W2001812580 cites W2169828269 @default.
• W2001812580 cites W2171465385 @default.
• W2001812580 cites W2278210606 @default.
• W2001812580 cites W227956821 @default.
• W2001812580 cites W2294196596 @default.
• W2001812580 cites W2329900079 @default.
• W2001812580 cites W2331260546 @default.
• W2001812580 cites W2338876929 @default.
• W2001812580 cites W2396993050 @default.
• W2001812580 cites W2409238204 @default.
• W2001812580 cites W2463159307 @default.
• W2001812580 cites W2794242766 @default.

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