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- W2001824364 abstract "The effects of tazobactam, a relatively new beta-lactamase inhibitor, were investigated on growth and penicillin-binding proteins (PBPs) of Borrellia burgdorferi. A previous communication from our group demonstrated several proteins capable of binding labelled penicillin in this organism. Of these proteins, 94-kDa and 57-kDa PBPs possessed the highest affinity for penicillin and were assumed to be essential proteins involved in cell-wall synthesis. In these experiments, tazobactam was used in competition binding experiments as well as on whole spirochetes. Only the 94-kDa and 57-kDa PBPs were affected by increasing amounts of tazobactam during competition-binding experiments and growth of B. burgdorferi was also inhibited. These results may explain the in vitro activity of beta-lactamase inhibitors in general and suggest a utility for these compounds when examining PBPs with hydrolysing activity and/or organisms with beta-lactamases." @default.
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- W2001824364 date "1991-07-15" @default.
- W2001824364 modified "2023-09-25" @default.
- W2001824364 title "Effect of a β-lactamase inhibitor, tazobactam, on growth and penicillin-binding proteins of Borrelia burgdorferi" @default.
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- W2001824364 doi "https://doi.org/10.1016/0378-1097(91)90430-i" @default.
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