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- W2001827070 abstract "Nerve Growth Factor (NGF) is known to elicit several distinct responses from its target neurons. Three different responses were exploited as bases for an assay method for NGF: (i) the traditional neurite outgrowth from 8-day chick embryo dorsal root ganglia (DRG) in modified explant culture, (ii) survival of neonatal mouse DRG neurons in monolayer cell culture, and (iii) extrusion of 22Na+ from chick embryo DRG neurons preloaded under conditions of NGF deprivation, in cell suspension. All three procedures were able to detect as little as 0.01 to 0.03 biological unit (BU) NGF/ml (about 10−11m). Nerve growth factor-like activity was examined in a number of human sera samples. None of the sera tested elicited a positive response with any of the three assay methods, indicating that if NGF was present, it would be at less than 0.1 to 0.2 BU/ml of undiluted serum. Human sera did not prevent genuine NGF from producing a positive response in these assays. Sera from patients with familial dysautonomia, an inherited neurologic disease suspected of having an altered concentration of circulating NGF, were also negative." @default.
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- W2001827070 date "1982-06-01" @default.
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- W2001827070 title "Three independent biological assays for nerve growth factor: No measurable activity in human sera" @default.
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- W2001827070 doi "https://doi.org/10.1016/0014-4886(82)90132-7" @default.
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