Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001830012> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2001830012 endingPage "206" @default.
- W2001830012 startingPage "203" @default.
- W2001830012 abstract "Haemophilia A is the most common X-chromosomal-linked congenital bleeding disorder and is caused by decreased activity of blood coagulation factor VIII. Affected individuals develop a variable phenotype of haemorrhages, mainly into joints and muscles depending on the amount of the residual factor VIII. The exogenous factor VIII-substitution by plasma-derived or recombinant products are the only treatments either on demand or prophylactically. The most important complication of treatment is the development of inhibitors that affect about 20%-50% of the severe cases. These antibodies neutralize the therapeutic effect of factor VIII-concentrates, leading to recurrent bleeding episodes, progredient joint damages and sometimes life-threatening situations. The only chance for a complete and permanent eradication of the inhibitors in these patients is the induction of Immune-Tolerance (ITT) to substituted factor VIII by the application of high-doses of factor VIII. The treatment demands a strict compliance of the patient and a much higher effort of the physician, to non-compared inhibitor patients. Requirements for a consistent realization of the ITT to increase the successful outcome was carried out by German Haemophilia Center Directors." @default.
- W2001830012 created "2016-06-24" @default.
- W2001830012 creator A5001620770 @default.
- W2001830012 creator A5074057493 @default.
- W2001830012 creator A5079123048 @default.
- W2001830012 creator A5081448568 @default.
- W2001830012 creator A5090513096 @default.
- W2001830012 date "1999-05-01" @default.
- W2001830012 modified "2023-10-10" @default.
- W2001830012 title "German recommendations for immune tolerance therapy in type A haemophiliacs with antibodies" @default.
- W2001830012 cites W1528709070 @default.
- W2001830012 cites W1983707924 @default.
- W2001830012 cites W2021047792 @default.
- W2001830012 cites W2050510640 @default.
- W2001830012 cites W2103793215 @default.
- W2001830012 cites W2148505112 @default.
- W2001830012 cites W2149564822 @default.
- W2001830012 cites W2417605240 @default.
- W2001830012 cites W2734698134 @default.
- W2001830012 cites W2809831076 @default.
- W2001830012 cites W58047943 @default.
- W2001830012 doi "https://doi.org/10.1046/j.1365-2516.1999.00311.x" @default.
- W2001830012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10444288" @default.
- W2001830012 hasPublicationYear "1999" @default.
- W2001830012 type Work @default.
- W2001830012 sameAs 2001830012 @default.
- W2001830012 citedByCount "51" @default.
- W2001830012 countsByYear W20018300122012 @default.
- W2001830012 countsByYear W20018300122013 @default.
- W2001830012 countsByYear W20018300122014 @default.
- W2001830012 countsByYear W20018300122015 @default.
- W2001830012 countsByYear W20018300122017 @default.
- W2001830012 countsByYear W20018300122018 @default.
- W2001830012 countsByYear W20018300122020 @default.
- W2001830012 countsByYear W20018300122022 @default.
- W2001830012 crossrefType "journal-article" @default.
- W2001830012 hasAuthorship W2001830012A5001620770 @default.
- W2001830012 hasAuthorship W2001830012A5074057493 @default.
- W2001830012 hasAuthorship W2001830012A5079123048 @default.
- W2001830012 hasAuthorship W2001830012A5081448568 @default.
- W2001830012 hasAuthorship W2001830012A5090513096 @default.
- W2001830012 hasConcept C126322002 @default.
- W2001830012 hasConcept C141071460 @default.
- W2001830012 hasConcept C159654299 @default.
- W2001830012 hasConcept C203014093 @default.
- W2001830012 hasConcept C2777232031 @default.
- W2001830012 hasConcept C2777702733 @default.
- W2001830012 hasConcept C2778382381 @default.
- W2001830012 hasConcept C2778385053 @default.
- W2001830012 hasConcept C71924100 @default.
- W2001830012 hasConcept C8891405 @default.
- W2001830012 hasConceptScore W2001830012C126322002 @default.
- W2001830012 hasConceptScore W2001830012C141071460 @default.
- W2001830012 hasConceptScore W2001830012C159654299 @default.
- W2001830012 hasConceptScore W2001830012C203014093 @default.
- W2001830012 hasConceptScore W2001830012C2777232031 @default.
- W2001830012 hasConceptScore W2001830012C2777702733 @default.
- W2001830012 hasConceptScore W2001830012C2778382381 @default.
- W2001830012 hasConceptScore W2001830012C2778385053 @default.
- W2001830012 hasConceptScore W2001830012C71924100 @default.
- W2001830012 hasConceptScore W2001830012C8891405 @default.
- W2001830012 hasIssue "3" @default.
- W2001830012 hasLocation W20018300121 @default.
- W2001830012 hasLocation W20018300122 @default.
- W2001830012 hasOpenAccess W2001830012 @default.
- W2001830012 hasPrimaryLocation W20018300121 @default.
- W2001830012 hasRelatedWork W1995822104 @default.
- W2001830012 hasRelatedWork W2005719195 @default.
- W2001830012 hasRelatedWork W2067082011 @default.
- W2001830012 hasRelatedWork W2086676349 @default.
- W2001830012 hasRelatedWork W2101928171 @default.
- W2001830012 hasRelatedWork W2145399350 @default.
- W2001830012 hasRelatedWork W2166990743 @default.
- W2001830012 hasRelatedWork W3113163854 @default.
- W2001830012 hasRelatedWork W3155450815 @default.
- W2001830012 hasRelatedWork W4233505807 @default.
- W2001830012 hasVolume "5" @default.
- W2001830012 isParatext "false" @default.
- W2001830012 isRetracted "false" @default.
- W2001830012 magId "2001830012" @default.
- W2001830012 workType "article" @default.