FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001831974> ?p ?o ?g. }

• W2001831974 endingPage "170" @default.
• W2001831974 startingPage "163" @default.
• W2001831974 abstract "Patients with the refractory anemia (RA) subtype of myelodysplastic syndrome who undergo allogeneic bone marrow transplantation (BMT) have a low risk of relapse, but they have a high risk of nonrelapse mortality when prepared with conventional preparative regimens. To try to reduce nonrelapse mortality, we treated 14 RA patients with a modified approach to total body irradiation (TBI) followed by cyclophosphamide (CY) and HLA-identical sibling BMT. Median patient age was 44 years (range, 28 to 65 years). Patients received TBI with shielding of the right lobe of the liver and both lungs followed by electron beam boosts to shielded ribs. Total radiation exposure in nonshielded areas was 12 Gy (n = 10), 10 Gy (n = 3), or 6 Gy (n = 1). After TBI, patients received CY at 120 mg/kg over 2 days, followed by transplantation of unmanipulated bone marrow. All patients initially achieved engraftment with donor cells, although 2 patients had subsequent reemergence of host hematopoiesis without evidence of disease relapse. Five patients died of transplantation-related causes between 22 and 1262 days post-BMT. Four patients relapsed between 157 and 1096 days post-BMT. These 14 patients were compared with 46 historical controls with RA who received conventional CY/TBI or busulfan/CY preparative regimens. Patients in the experimental group had a similar nonrelapse mortality rate compared with the historical control group (29% versus 37%, respectively; P = .8), but a higher relapse rate (34% versus 2%, P = .0004) and a lower disease-free survival (38% versus 61%, P = .16). We conclude that this modified TBI approach is associated with an unacceptably high risk of relapse for patients with RA undergoing BMT." @default.
• W2001831974 created "2016-06-24" @default.
• W2001831974 creator A5016644532 @default.
• W2001831974 creator A5030315676 @default.
• W2001831974 creator A5037538071 @default.
• W2001831974 creator A5045089433 @default.
• W2001831974 creator A5056405520 @default.
• W2001831974 creator A5083011083 @default.
• W2001831974 creator A5085787488 @default.
• W2001831974 date "2001-03-01" @default.
• W2001831974 modified "2023-10-01" @default.
• W2001831974 title "Relapse after allogeneic bone marrow transplantation for refractory anemia is increased by shielding lungs and liver during total body irradiation" @default.
• W2001831974 cites W100647374 @default.
• W2001831974 cites W1479909146 @default.
• W2001831974 cites W1487950379 @default.
• W2001831974 cites W149003550 @default.
• W2001831974 cites W1661742470 @default.
• W2001831974 cites W175346118 @default.
• W2001831974 cites W1870843212 @default.
• W2001831974 cites W187238933 @default.
• W2001831974 cites W1923887607 @default.
• W2001831974 cites W1934085618 @default.
• W2001831974 cites W1974919527 @default.
• W2001831974 cites W1979300931 @default.
• W2001831974 cites W2012940838 @default.
• W2001831974 cites W2054582792 @default.
• W2001831974 cites W2069566335 @default.
• W2001831974 cites W2069895841 @default.
• W2001831974 cites W2076426515 @default.
• W2001831974 cites W2078301067 @default.
• W2001831974 cites W2133971354 @default.
• W2001831974 cites W2150113701 @default.
• W2001831974 cites W2162169816 @default.
• W2001831974 cites W2172296959 @default.
• W2001831974 cites W2241784197 @default.
• W2001831974 cites W2255045134 @default.
• W2001831974 cites W2278599555 @default.
• W2001831974 cites W2337969406 @default.
• W2001831974 cites W2410096256 @default.
• W2001831974 cites W2416167958 @default.
• W2001831974 cites W24911164 @default.
• W2001831974 cites W3112391182 @default.
• W2001831974 cites W347010909 @default.
• W2001831974 cites W1983392832 @default.
• W2001831974 doi "https://doi.org/10.1053/bbmt.2001.v7.pm11302550" @default.
• W2001831974 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11302550" @default.
• W2001831974 hasPublicationYear "2001" @default.
• W2001831974 type Work @default.
• W2001831974 sameAs 2001831974 @default.
• W2001831974 citedByCount "21" @default.
• W2001831974 countsByYear W20018319742012 @default.
• W2001831974 countsByYear W20018319742013 @default.
• W2001831974 countsByYear W20018319742015 @default.
• W2001831974 countsByYear W20018319742017 @default.
• W2001831974 countsByYear W20018319742018 @default.
• W2001831974 countsByYear W20018319742019 @default.
• W2001831974 countsByYear W20018319742020 @default.
• W2001831974 countsByYear W20018319742023 @default.
• W2001831974 crossrefType "journal-article" @default.
• W2001831974 hasAuthorship W2001831974A5016644532 @default.
• W2001831974 hasAuthorship W2001831974A5030315676 @default.
• W2001831974 hasAuthorship W2001831974A5037538071 @default.
• W2001831974 hasAuthorship W2001831974A5045089433 @default.
• W2001831974 hasAuthorship W2001831974A5056405520 @default.
• W2001831974 hasAuthorship W2001831974A5083011083 @default.
• W2001831974 hasAuthorship W2001831974A5085787488 @default.
• W2001831974 hasBestOaLocation W20018319741 @default.
• W2001831974 hasConcept C126322002 @default.
• W2001831974 hasConcept C141071460 @default.
• W2001831974 hasConcept C2776694085 @default.
• W2001831974 hasConcept C2776755627 @default.
• W2001831974 hasConcept C2777408962 @default.
• W2001831974 hasConcept C2778248108 @default.
• W2001831974 hasConcept C2778880498 @default.
• W2001831974 hasConcept C2780007613 @default.
• W2001831974 hasConcept C2780611847 @default.
• W2001831974 hasConcept C2911091166 @default.
• W2001831974 hasConcept C71924100 @default.
• W2001831974 hasConcept C90924648 @default.
• W2001831974 hasConceptScore W2001831974C126322002 @default.
• W2001831974 hasConceptScore W2001831974C141071460 @default.
• W2001831974 hasConceptScore W2001831974C2776694085 @default.
• W2001831974 hasConceptScore W2001831974C2776755627 @default.
• W2001831974 hasConceptScore W2001831974C2777408962 @default.
• W2001831974 hasConceptScore W2001831974C2778248108 @default.
• W2001831974 hasConceptScore W2001831974C2778880498 @default.
• W2001831974 hasConceptScore W2001831974C2780007613 @default.
• W2001831974 hasConceptScore W2001831974C2780611847 @default.
• W2001831974 hasConceptScore W2001831974C2911091166 @default.
• W2001831974 hasConceptScore W2001831974C71924100 @default.
• W2001831974 hasConceptScore W2001831974C90924648 @default.
• W2001831974 hasIssue "3" @default.
• W2001831974 hasLocation W20018319741 @default.
• W2001831974 hasLocation W20018319742 @default.
• W2001831974 hasOpenAccess W2001831974 @default.
• W2001831974 hasPrimaryLocation W20018319741 @default.
• W2001831974 hasRelatedWork W2072244040 @default.
• W2001831974 hasRelatedWork W2091710908 @default.

• next