FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001837863> ?p ?o ?g. }

• W2001837863 endingPage "660" @default.
• W2001837863 startingPage "646" @default.
• W2001837863 abstract "The Hoxa2 gene is an important component of regulatory events during hindbrain segmentation and head development in vertebrates. In this study we have used sequenced comparisons of the Hoxa2 locus from 12 vertebrate species in combination with detailed regulatory analyses in mouse and chicken embryos to characterize the mechanistic basis for the regulation of Hoxa2 in rhombomere (r) 4. A highly conserved region in the Hoxa2 intron functions as an r4 enhancer. In vitro binding studies demonstrate that within the conserved region three bipartite Hox/Pbx binding sites (PH1–PH3) in combination with a single binding site for Pbx–Prep/Meis (PM) heterodimers co-operate to regulate enhancer activity in r4. Mutational analysis reveals that these sites are required for activity of the enhancer, suggesting that the r4 enhancer from Hoxa2 functions in vivo as a Hox-response module in combination with the Hox cofactors, Pbx and Prep/Meis. Furthermore, this r4 enhancer is capable of mediating a response to ectopic HOXB1 expression in the hindbrain. These findings reveal that Hoxa2 is a target gene of Hoxb1 and permit us to develop a gene regulatory network for r4, whereby Hoxa2, along with Hoxb1, Hoxb2 and Hoxa1, is integrated into a series of auto- and cross-regulatory loops between Hox genes. These data highlight the important role played by direct cross-talk between Hox genes in regulating hindbrain patterning." @default.
• W2001837863 created "2016-06-24" @default.
• W2001837863 creator A5012734348 @default.
• W2001837863 creator A5022732047 @default.
• W2001837863 creator A5037100565 @default.
• W2001837863 creator A5041567751 @default.
• W2001837863 creator A5064551109 @default.
• W2001837863 creator A5077282419 @default.
• W2001837863 date "2007-02-01" @default.
• W2001837863 modified "2023-10-18" @default.
• W2001837863 title "Expression of Hoxa2 in rhombomere 4 is regulated by a conserved cross-regulatory mechanism dependent upon Hoxb1" @default.
• W2001837863 cites W1556057172 @default.
• W2001837863 cites W1784887600 @default.
• W2001837863 cites W1966299515 @default.
• W2001837863 cites W1968199309 @default.
• W2001837863 cites W1975969255 @default.
• W2001837863 cites W1982914586 @default.
• W2001837863 cites W1987725277 @default.
• W2001837863 cites W1989591599 @default.
• W2001837863 cites W1989823353 @default.
• W2001837863 cites W1993817680 @default.
• W2001837863 cites W1994340993 @default.
• W2001837863 cites W1998020029 @default.
• W2001837863 cites W2006877541 @default.
• W2001837863 cites W2008668462 @default.
• W2001837863 cites W2009851083 @default.
• W2001837863 cites W2012201162 @default.
• W2001837863 cites W2014507351 @default.
• W2001837863 cites W2016686483 @default.
• W2001837863 cites W2017845174 @default.
• W2001837863 cites W2023003508 @default.
• W2001837863 cites W2032212808 @default.
• W2001837863 cites W2038459597 @default.
• W2001837863 cites W2039007871 @default.
• W2001837863 cites W2042350827 @default.
• W2001837863 cites W2046859370 @default.
• W2001837863 cites W2054160429 @default.
• W2001837863 cites W2054486613 @default.
• W2001837863 cites W2057433337 @default.
• W2001837863 cites W2061191160 @default.
• W2001837863 cites W2070815798 @default.
• W2001837863 cites W2071880700 @default.
• W2001837863 cites W2072083009 @default.
• W2001837863 cites W2073497058 @default.
• W2001837863 cites W2081748379 @default.
• W2001837863 cites W2096000660 @default.
• W2001837863 cites W2099612400 @default.
• W2001837863 cites W2099715509 @default.
• W2001837863 cites W2104964229 @default.
• W2001837863 cites W2105244370 @default.
• W2001837863 cites W2105516199 @default.
• W2001837863 cites W2106218592 @default.
• W2001837863 cites W2106882534 @default.
• W2001837863 cites W2113812441 @default.
• W2001837863 cites W2115754306 @default.
• W2001837863 cites W2117602892 @default.
• W2001837863 cites W2120352535 @default.
• W2001837863 cites W2122980330 @default.
• W2001837863 cites W2124147667 @default.
• W2001837863 cites W2125161163 @default.
• W2001837863 cites W2125726816 @default.
• W2001837863 cites W2131510900 @default.
• W2001837863 cites W2135980041 @default.
• W2001837863 cites W2137075959 @default.
• W2001837863 cites W2143600444 @default.
• W2001837863 cites W2144473089 @default.
• W2001837863 cites W2154279879 @default.
• W2001837863 cites W2157679927 @default.
• W2001837863 cites W2161272023 @default.
• W2001837863 cites W2166425787 @default.
• W2001837863 cites W2183969585 @default.
• W2001837863 cites W2184942504 @default.
• W2001837863 cites W2187084543 @default.
• W2001837863 cites W2188280059 @default.
• W2001837863 cites W2188520922 @default.
• W2001837863 cites W2218754414 @default.
• W2001837863 cites W2276923998 @default.
• W2001837863 cites W2282572666 @default.
• W2001837863 cites W4229918205 @default.
• W2001837863 cites W4361805501 @default.
• W2001837863 cites W46841966 @default.
• W2001837863 cites W939540729 @default.
• W2001837863 doi "https://doi.org/10.1016/j.ydbio.2006.10.029" @default.
• W2001837863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17113575" @default.
• W2001837863 hasPublicationYear "2007" @default.
• W2001837863 type Work @default.
• W2001837863 sameAs 2001837863 @default.
• W2001837863 citedByCount "77" @default.
• W2001837863 countsByYear W20018378632012 @default.
• W2001837863 countsByYear W20018378632013 @default.
• W2001837863 countsByYear W20018378632014 @default.
• W2001837863 countsByYear W20018378632015 @default.
• W2001837863 countsByYear W20018378632016 @default.
• W2001837863 countsByYear W20018378632017 @default.
• W2001837863 countsByYear W20018378632018 @default.
• W2001837863 countsByYear W20018378632019 @default.
• W2001837863 countsByYear W20018378632020 @default.
• W2001837863 countsByYear W20018378632021 @default.

• next