Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001840281> ?p ?o ?g. }
- W2001840281 endingPage "48" @default.
- W2001840281 startingPage "37" @default.
- W2001840281 abstract "The interaction between the amphiphilic drug amitriptyline hydrochloride (AMT) and the nonionic surfactants used in drug delivery has been investigated. Herein, we report the micellization behavior of AMT in presence of ethoxylated alkyl phenols in aqueous medium and the clouding phenomenon in the absence and presence of different nonionic surfactants in buffer solution. The values of critical micelle concentration (CMC) of AMT obtained using the conductivity method, decrease as nonionic surfactant concentration increases. With an increase in temperature, the CMC first increases and then decreases. At 303.15 K, the maximum CMC values were obtained with or without nonionic surfactant. The results obtained indicate attractive interactions (synergism) between the two mixing amphiphiles in solution. The experimentally obtained critical micelle concentration (CMC) values are always lower than ideal CMC values. Micellar mole fraction (X1) values, calculated by different proposed models, show the contribution of nonionic surfactant concentration. At a fixed drug concentration (50 mmol kg−1) and pH (=6.7) nonionic surfactants show continuous increase in cloud point (CP). Increase in drug concentration and pH, in the presence of fixed amounts of nonionic surfactant, increases and decreases the CP, respectively." @default.
- W2001840281 created "2016-06-24" @default.
- W2001840281 creator A5016427171 @default.
- W2001840281 creator A5030722559 @default.
- W2001840281 creator A5049708663 @default.
- W2001840281 creator A5062032042 @default.
- W2001840281 creator A5063236562 @default.
- W2001840281 creator A5067477167 @default.
- W2001840281 creator A5087568651 @default.
- W2001840281 date "2013-03-05" @default.
- W2001840281 modified "2023-09-24" @default.
- W2001840281 title "Aggregation and Phase Separation Phenomenon of Amitriptyline Hydrochloride Under the Influence of Pharmaceutical Excipients" @default.
- W2001840281 cites W1662084969 @default.
- W2001840281 cites W1975484821 @default.
- W2001840281 cites W1983003276 @default.
- W2001840281 cites W1983859555 @default.
- W2001840281 cites W1990700311 @default.
- W2001840281 cites W1994466452 @default.
- W2001840281 cites W1996777874 @default.
- W2001840281 cites W1998327788 @default.
- W2001840281 cites W2001447583 @default.
- W2001840281 cites W2003398981 @default.
- W2001840281 cites W2005209160 @default.
- W2001840281 cites W2005560843 @default.
- W2001840281 cites W2005770637 @default.
- W2001840281 cites W2007466352 @default.
- W2001840281 cites W2008850158 @default.
- W2001840281 cites W2015812088 @default.
- W2001840281 cites W2023369820 @default.
- W2001840281 cites W2028495667 @default.
- W2001840281 cites W2030368891 @default.
- W2001840281 cites W2032863714 @default.
- W2001840281 cites W2034611491 @default.
- W2001840281 cites W2043136868 @default.
- W2001840281 cites W2043630755 @default.
- W2001840281 cites W2043891018 @default.
- W2001840281 cites W2047138628 @default.
- W2001840281 cites W2053417217 @default.
- W2001840281 cites W2053537956 @default.
- W2001840281 cites W2058864302 @default.
- W2001840281 cites W2065970656 @default.
- W2001840281 cites W2069853899 @default.
- W2001840281 cites W2073203385 @default.
- W2001840281 cites W2081307328 @default.
- W2001840281 cites W2084099308 @default.
- W2001840281 cites W2087111913 @default.
- W2001840281 cites W2093757611 @default.
- W2001840281 cites W2100520064 @default.
- W2001840281 cites W2141379475 @default.
- W2001840281 cites W2144069837 @default.
- W2001840281 cites W2160405244 @default.
- W2001840281 cites W2168361657 @default.
- W2001840281 cites W2236315462 @default.
- W2001840281 cites W4255135972 @default.
- W2001840281 doi "https://doi.org/10.1007/s11743-013-1461-5" @default.
- W2001840281 hasPublicationYear "2013" @default.
- W2001840281 type Work @default.
- W2001840281 sameAs 2001840281 @default.
- W2001840281 citedByCount "5" @default.
- W2001840281 countsByYear W20018402812015 @default.
- W2001840281 countsByYear W20018402812016 @default.
- W2001840281 countsByYear W20018402812018 @default.
- W2001840281 countsByYear W20018402812021 @default.
- W2001840281 countsByYear W20018402812022 @default.
- W2001840281 crossrefType "journal-article" @default.
- W2001840281 hasAuthorship W2001840281A5016427171 @default.
- W2001840281 hasAuthorship W2001840281A5030722559 @default.
- W2001840281 hasAuthorship W2001840281A5049708663 @default.
- W2001840281 hasAuthorship W2001840281A5062032042 @default.
- W2001840281 hasAuthorship W2001840281A5063236562 @default.
- W2001840281 hasAuthorship W2001840281A5067477167 @default.
- W2001840281 hasAuthorship W2001840281A5087568651 @default.
- W2001840281 hasConcept C11268172 @default.
- W2001840281 hasConcept C178790620 @default.
- W2001840281 hasConcept C184651966 @default.
- W2001840281 hasConcept C185592680 @default.
- W2001840281 hasConcept C22673317 @default.
- W2001840281 hasConcept C2780263894 @default.
- W2001840281 hasConcept C2994558038 @default.
- W2001840281 hasConcept C43617362 @default.
- W2001840281 hasConcept C55493867 @default.
- W2001840281 hasConcept C58226133 @default.
- W2001840281 hasConcept C64237528 @default.
- W2001840281 hasConcept C68348359 @default.
- W2001840281 hasConceptScore W2001840281C11268172 @default.
- W2001840281 hasConceptScore W2001840281C178790620 @default.
- W2001840281 hasConceptScore W2001840281C184651966 @default.
- W2001840281 hasConceptScore W2001840281C185592680 @default.
- W2001840281 hasConceptScore W2001840281C22673317 @default.
- W2001840281 hasConceptScore W2001840281C2780263894 @default.
- W2001840281 hasConceptScore W2001840281C2994558038 @default.
- W2001840281 hasConceptScore W2001840281C43617362 @default.
- W2001840281 hasConceptScore W2001840281C55493867 @default.
- W2001840281 hasConceptScore W2001840281C58226133 @default.
- W2001840281 hasConceptScore W2001840281C64237528 @default.
- W2001840281 hasConceptScore W2001840281C68348359 @default.
- W2001840281 hasIssue "1" @default.
- W2001840281 hasLocation W20018402811 @default.