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- W2001848966 abstract "The protein bound anti-rheumatic drugs salicylate, indomethacin, oxyphenbutazone and sulindac inhibit human and calf lens aldose reductase. Against human cataract aldose reductase the IC50 is 1×10−7 m for sulindac, 1×10−5 m for indomethacin, 5×10−4 m for salicylate and 5×10−3 m for oxyphenbutazone. These drugs which have had widespread clinical use in humans inhibit human senile cataract aldose reductase non-competitively with either dl -glyceraldehyde or d -glucose as substrate. The effectiveness of the anti-rheumatic agents as inhibitors of aldose reductase may be enhanced by binding to lens proteins and retention inside the lens (or cataract) for prolonged periods of time." @default.
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- W2001848966 date "1982-07-01" @default.
- W2001848966 modified "2023-09-24" @default.
- W2001848966 title "Inhibition of lens and cataract aldose reductase by protein-bound anti-rheumatic drugs: Salicylate, indomethacin, oxyphenbutazone, sulindac" @default.
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- W2001848966 doi "https://doi.org/10.1016/s0014-4835(82)80019-5" @default.
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