Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001856285> ?p ?o ?g. }
- W2001856285 endingPage "29" @default.
- W2001856285 startingPage "13" @default.
- W2001856285 abstract "A novel series of trisubstituted acridines were synthesized with the aim of mimicking the effects of BRACO19. These compounds were synthesized by modifying the molecular structure of BRACO19 at positions 3 and 6 with heteroacyclic moieties. All of the derivatives presented in the study exhibited stabilizing effects on the human telomeric DNA quadruplex. UV-vis spectroscopy, circular dichroism, linear dichroism and viscosimetry were used in order to study the nature of the DNA binding in more detail. The results show that all of the novel derivatives were able to fold the single-stranded DNA sequences into antiparallel G-quadruplex structures, with derivative 15 exhibiting the highest stabilizing capability. Cell cycle analysis revealed that a primary trend of the braco-like derivatives was to arrest the cells in the S- and G2M-phases of the cell cycle within the first 72h, with derivative 13 and BRACO19 proving particularly effective in suppressing cell proliferation. All studies derivatives were less toxic to human fibroblast cell line in comparison with HT 29 cancer cell line." @default.
- W2001856285 created "2016-06-24" @default.
- W2001856285 creator A5000639286 @default.
- W2001856285 creator A5006189027 @default.
- W2001856285 creator A5014490392 @default.
- W2001856285 creator A5019962548 @default.
- W2001856285 creator A5020286203 @default.
- W2001856285 creator A5031419076 @default.
- W2001856285 creator A5038375683 @default.
- W2001856285 creator A5041723701 @default.
- W2001856285 creator A5050920826 @default.
- W2001856285 creator A5052717896 @default.
- W2001856285 creator A5053329693 @default.
- W2001856285 creator A5062168572 @default.
- W2001856285 creator A5069815389 @default.
- W2001856285 creator A5074839041 @default.
- W2001856285 creator A5076275145 @default.
- W2001856285 creator A5081885555 @default.
- W2001856285 creator A5091477059 @default.
- W2001856285 date "2014-12-01" @default.
- W2001856285 modified "2023-10-17" @default.
- W2001856285 title "Novel trisubstituted acridines as human telomeric quadruplex binding ligands" @default.
- W2001856285 cites W1496772673 @default.
- W2001856285 cites W1963799772 @default.
- W2001856285 cites W1965272410 @default.
- W2001856285 cites W1970206555 @default.
- W2001856285 cites W1974455675 @default.
- W2001856285 cites W1976499671 @default.
- W2001856285 cites W1977476599 @default.
- W2001856285 cites W1978809288 @default.
- W2001856285 cites W1980595949 @default.
- W2001856285 cites W1981013674 @default.
- W2001856285 cites W1985104078 @default.
- W2001856285 cites W1986796166 @default.
- W2001856285 cites W1987006829 @default.
- W2001856285 cites W1991950561 @default.
- W2001856285 cites W1993206757 @default.
- W2001856285 cites W1995391714 @default.
- W2001856285 cites W1999164938 @default.
- W2001856285 cites W2000971601 @default.
- W2001856285 cites W2002647840 @default.
- W2001856285 cites W2009139426 @default.
- W2001856285 cites W2010947710 @default.
- W2001856285 cites W2012775604 @default.
- W2001856285 cites W2015688756 @default.
- W2001856285 cites W2020249839 @default.
- W2001856285 cites W2025811126 @default.
- W2001856285 cites W2027420997 @default.
- W2001856285 cites W2028526843 @default.
- W2001856285 cites W2038786052 @default.
- W2001856285 cites W2046229956 @default.
- W2001856285 cites W2048165645 @default.
- W2001856285 cites W2051135292 @default.
- W2001856285 cites W2053166926 @default.
- W2001856285 cites W2055464525 @default.
- W2001856285 cites W2057984962 @default.
- W2001856285 cites W2080110153 @default.
- W2001856285 cites W2081335209 @default.
- W2001856285 cites W2084016670 @default.
- W2001856285 cites W2092324565 @default.
- W2001856285 cites W2092476508 @default.
- W2001856285 cites W2092621209 @default.
- W2001856285 cites W2101785907 @default.
- W2001856285 cites W2105759091 @default.
- W2001856285 cites W2114644061 @default.
- W2001856285 cites W2116609429 @default.
- W2001856285 cites W2120403752 @default.
- W2001856285 cites W2123525790 @default.
- W2001856285 cites W2129800037 @default.
- W2001856285 cites W2131288855 @default.
- W2001856285 cites W2132629607 @default.
- W2001856285 cites W2147993766 @default.
- W2001856285 cites W2150981663 @default.
- W2001856285 cites W2157970694 @default.
- W2001856285 cites W2158534713 @default.
- W2001856285 cites W2160001764 @default.
- W2001856285 cites W2163579602 @default.
- W2001856285 cites W2165526004 @default.
- W2001856285 cites W2171830519 @default.
- W2001856285 cites W2257547252 @default.
- W2001856285 cites W2506200838 @default.
- W2001856285 doi "https://doi.org/10.1016/j.bioorg.2014.07.010" @default.
- W2001856285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25171773" @default.
- W2001856285 hasPublicationYear "2014" @default.
- W2001856285 type Work @default.
- W2001856285 sameAs 2001856285 @default.
- W2001856285 citedByCount "20" @default.
- W2001856285 countsByYear W20018562852015 @default.
- W2001856285 countsByYear W20018562852016 @default.
- W2001856285 countsByYear W20018562852017 @default.
- W2001856285 countsByYear W20018562852018 @default.
- W2001856285 countsByYear W20018562852019 @default.
- W2001856285 countsByYear W20018562852020 @default.
- W2001856285 countsByYear W20018562852021 @default.
- W2001856285 countsByYear W20018562852022 @default.
- W2001856285 countsByYear W20018562852023 @default.
- W2001856285 crossrefType "journal-article" @default.
- W2001856285 hasAuthorship W2001856285A5000639286 @default.