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• W2001873927 abstract "A novel plant-specific type III polyketide synthase (PKS) that catalyzes formation of a pentaketide chromone, 5,7-dihydroxy-2-methylchromone, from five molecules of malonyl-CoA, was cloned and sequenced from aloe (Aloe arborescens). Site-directed mutagenesis revealed that Met207 (corresponding to Thr197 in CHS) determines the polyketide chain length and the product specificity of the enzyme; remarkably, replacement of a single amino acid residue, Met207, with Gly yielded a mutant enzyme that efficiently produces aromatic octaketides, SEK4 and SEK4b, the products of the minimal PKS for actinorhodin (act from Streptomyces coelicolor), from eight molecules of malonyl-CoA. This provided new insights into the catalytic functions and specificities of the CHS-superfamily type III PKS enzymes." @default.
• W2001873927 created "2016-06-24" @default.
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• W2001873927 date "2005-01-14" @default.
• W2001873927 modified "2023-10-02" @default.
• W2001873927 title "A Plant Type III Polyketide Synthase that Produces Pentaketide Chromone" @default.
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• W2001873927 doi "https://doi.org/10.1021/ja0431206" @default.
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