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- W2001874462 abstract "Abstract Heteroanalogues of angelicin, pyrrolo[3,2‐ h ]quinazolines, were synthesized with the aim of obtaining new potent photochemotherapeutic agents. Many derivatives caused a significant decrease in cell proliferation in several human tumor cell lines after irradiation with UVA light (GI 50 =15.2–0.2 μ M ). Their phototoxicity effected apoptosis in Jurkat cells with the involvement of mitochondria (as determined by the loss of mitochondrial membrane potential and production of reactive oxygen species) and lysosomes. The phototoxicity of these compounds could be explained by lipid peroxidation." @default.
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- W2001874462 date "2011-05-13" @default.
- W2001874462 modified "2023-09-30" @default.
- W2001874462 title "Pyrrolo[3,2-h]quinazolines as Photochemotherapeutic Agents" @default.
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- W2001874462 doi "https://doi.org/10.1002/cmdc.201100085" @default.
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