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• W2001874484 abstract "<h3>Objectives</h3> Men with low physical fitness and high occupational physical activity are recently shown to have an increased risk of cardiovascular disease and all-cause mortality. The association between occupational physical activity with cardiovascular disease and all-cause mortality may also depend on leisure time physical activity. <h3>Design</h3> A prospective cohort study. <h3>Setting</h3> The Copenhagen City Heart Study. <h3>Participants</h3> 7819 men and women aged 25–66 years without a history of cardiovascular disease who attended an initial examination in the Copenhagen City Heart Study in 1976–1978. <h3>Outcome measures</h3> Myocardial infarction and all-cause mortality. Occupational physical activity was defined by combining information from baseline (1976–1978) with reassessment in 1981–1983. Conventional risk factors were controlled for in Cox analyses. <h3>Results</h3> During the follow-up from 1976 to 1978 until 2010, 2888 subjects died of all-cause mortality and 787 had a first event of myocardial infarction. Overall, occupational physical activity predicted all-cause mortality and myocardial infarction in men but not in women (test for interaction p=0.02). High occupational physical activity was associated with an increased risk of all-cause mortality among men with low (HR 1.56; 95% CI 1.11 to 2.18) and moderate (HR 1.31; 95% CI 1.05 to 1.63) leisure time physical activity but not among men with high leisure time physical activity (HR 1.00; 95% CI 0.78 to 1.26) (test for interaction p=0.04). Similar but weaker tendencies were found for myocardial infarction. Among women, occupational physical activity was not associated with subsequent all-cause mortality or myocardial infarction. <h3>Conclusions</h3> The findings suggest that high occupational physical activity imposes harmful effects particularly among men with low levels of leisure time physical activity." @default.
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• W2001874484 date "2012-01-01" @default.
• W2001874484 modified "2023-09-30" @default.
• W2001874484 title "Occupational and leisure time physical activity: risk of all-cause mortality and myocardial infarction in the Copenhagen City Heart Study. A prospective cohort study" @default.
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• W2001874484 doi "https://doi.org/10.1136/bmjopen-2011-000556" @default.
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