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- W2001877978 abstract "Experiment 1 examined the dose response effects of posttrial injections of strychnine sulphate (0.012–1.25 mg/kg) on learning in mice. Injections were given each day immediately after 3 massed training trials on a food reward visual discrimination task. Facilitation was found with low (0.25, 0.05, 0.10 mg/kg) and high (1.0 and 1.25 mg/kg) doses, but not with intermediate doses (0.20, 0.40, 0.80 mg/kg). Experiment 2 examined the effects of time of pre- or posttrial drug injection of two doses: 0.10 and 1.00 mg/kg. With both doses significant facilitation of learning was obtained with posttrial injection intervals of one hour or less. With 1.0 mg/kg facilitation was obtained with all pretrial injection times examined (longest interval was 1 hr). With 0.10 mg/kg significant facilitation was obtained with injections given 30 min but not 60 min pretrial. These findings are interpreted as providing further evidence that strychnine facilitates learning by affecting posttrial neurobiological processes underlying memory storage." @default.
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- W2001877978 title "Strychnine effects on discrimination learning in mice: Effects of dose and time of administration" @default.
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- W2001877978 doi "https://doi.org/10.1016/0031-9384(70)90133-2" @default.
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