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• W2001902079 abstract "Early in development, the polysialylated form of the neural cell adhesion molecule (PSA-NCAM) is expressed by growth cones, neuronal processes, and neuronal cell bodies. In rat striatum, PSA-NCAM expression becomes progressively restricted to pre- and postsynaptic membranes and is undetectable by postnatal day 25 (P25), i.e., after corticostriatal synaptogenesis. This study examined the effects of cortical lesions performed on P14, when the corticostriatal projection is already primarily unilateral and cortical inputs have not yet formed asymmetric synapses on striatal neurons. Rats were killed on P25, and PSA-NCAM expression was examined by immunoblotting and immunohistochemistry with light and electron microscopy. In contrast to the case in controls, PSA-NCAM expression was maintained in the striatum of lesioned pups. Ultrastructural studies showed that PSA-NCAM was present 1) in growth cone-like structures and neuronal processes and 2) in striatal neurons. Together with the presence of growth cones, the observation that the number of asymmetric synapses was unchanged in the denervated striatum suggests that axonal sprouting occurred in response to the lesion. This was confirmed by axonal labeling in the denervated striatum after injection of Fluoro-Ruby in the contralateral cortex. The data indicate that P14 cortical lesions affect PSA-NCAM expression in the developing striatum 1) by inducing a robust axonal plasticity resulting in the presence of immature presynaptic elements that contain PSA-NCAM and 2) by delaying the loss of PSA-NCAM expression in striatal neurons, suggesting that the lesion affects the time course of striatal maturation. J. Comp. Neurol. 389:289–308, 1997. © 1997 Wiley-Liss, Inc." @default.
• W2001902079 created "2016-06-24" @default.
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• W2001902079 creator A5084350482 @default.
• W2001902079 date "1997-12-15" @default.
• W2001902079 modified "2023-10-03" @default.
• W2001902079 title "Regulation of the polysialylated form of the neural cell adhesion molecule in the developing striatum: Effects of cortical lesions" @default.
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• W2001902079 doi "https://doi.org/10.1002/(sici)1096-9861(19971215)389:2<289::aid-cne8>3.0.co;2-y" @default.
• W2001902079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9416923" @default.
• W2001902079 hasPublicationYear "1997" @default.
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