Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001904531> ?p ?o ?g. }
- W2001904531 abstract "Abstract In CNS lesions, “reactive astrocytes” form a prominent cellular response. However, the nature of this astrocyte immune activity is not well understood. In order to study astrocytic immune responses to inflammation and injury, we generated mice with conditional deletion of p38α (MAPK14) in GFAP+ astrocytes. We studied the role of p38α signaling in astrocyte immune activation both in vitro and in vivo and simultaneously examined the effects of astrocyte activation in CNS inflammation. Our results showed that specific subsets of cytokines (TNFα, IL-6) and chemokines (CCL2, CCL4, CXCL1, CXCL2, CXCL10) are critically regulated by p38α signaling in astrocytes. In an in vivo CNS inflammation model of intracerebral injection of LPS, we observed markedly attenuated astrogliosis in conditional GFAPcre p38α −/− mice. However, GFAPcre p38α −/− mice showed marked upregulation of CCL2, CCL3, CCL4, CXCL2, CXCL10, TNFα and IL-1β compared to p38αfl/fl cohorts, suggesting that in vivo responses to LPS after GFAPcre p38α deletion are complex and involve interactions between multiple cell types. This finding was supported by a prominent increase in macrophage/microglia and neutrophil recruitment in GFAPcre p38α −/− mice compared to p38αfl/fl controls. Together, these studies provide important insights into the critical role of p38α signaling in astrocyte immune activation." @default.
- W2001904531 created "2016-06-24" @default.
- W2001904531 creator A5001959448 @default.
- W2001904531 creator A5050051706 @default.
- W2001904531 creator A5064269789 @default.
- W2001904531 creator A5075667146 @default.
- W2001904531 creator A5083093401 @default.
- W2001904531 creator A5083348278 @default.
- W2001904531 date "2014-12-12" @default.
- W2001904531 modified "2023-10-16" @default.
- W2001904531 title "p38α (MAPK14) critically regulates the immunological response and the production of specific cytokines and chemokines in astrocytes" @default.
- W2001904531 cites W1490718717 @default.
- W2001904531 cites W1543452323 @default.
- W2001904531 cites W1552849491 @default.
- W2001904531 cites W1558962636 @default.
- W2001904531 cites W1565491355 @default.
- W2001904531 cites W1611449349 @default.
- W2001904531 cites W1630758895 @default.
- W2001904531 cites W178098991 @default.
- W2001904531 cites W1821663971 @default.
- W2001904531 cites W1896626713 @default.
- W2001904531 cites W1915946375 @default.
- W2001904531 cites W1942966726 @default.
- W2001904531 cites W1964089588 @default.
- W2001904531 cites W1966747379 @default.
- W2001904531 cites W1966771241 @default.
- W2001904531 cites W1966804156 @default.
- W2001904531 cites W1966894835 @default.
- W2001904531 cites W1967192722 @default.
- W2001904531 cites W1969223713 @default.
- W2001904531 cites W1970757672 @default.
- W2001904531 cites W1970816555 @default.
- W2001904531 cites W1970881264 @default.
- W2001904531 cites W1974131493 @default.
- W2001904531 cites W1982850249 @default.
- W2001904531 cites W1986331600 @default.
- W2001904531 cites W1988362929 @default.
- W2001904531 cites W1988867798 @default.
- W2001904531 cites W1990065094 @default.
- W2001904531 cites W1996826230 @default.
- W2001904531 cites W2003060606 @default.
- W2001904531 cites W2005470401 @default.
- W2001904531 cites W2012829023 @default.
- W2001904531 cites W2015541518 @default.
- W2001904531 cites W2023542419 @default.
- W2001904531 cites W2024136349 @default.
- W2001904531 cites W2025198517 @default.
- W2001904531 cites W2026577098 @default.
- W2001904531 cites W2028582197 @default.
- W2001904531 cites W2031931457 @default.
- W2001904531 cites W2032955465 @default.
- W2001904531 cites W2034184306 @default.
- W2001904531 cites W2036145275 @default.
- W2001904531 cites W2038141238 @default.
- W2001904531 cites W2038469447 @default.
- W2001904531 cites W2038969666 @default.
- W2001904531 cites W2039077632 @default.
- W2001904531 cites W2039850455 @default.
- W2001904531 cites W2044177663 @default.
- W2001904531 cites W2044950493 @default.
- W2001904531 cites W2045151906 @default.
- W2001904531 cites W2046557565 @default.
- W2001904531 cites W2047263793 @default.
- W2001904531 cites W2050318359 @default.
- W2001904531 cites W2054791134 @default.
- W2001904531 cites W2056176542 @default.
- W2001904531 cites W2058623137 @default.
- W2001904531 cites W2059830137 @default.
- W2001904531 cites W2062010118 @default.
- W2001904531 cites W2065054922 @default.
- W2001904531 cites W2067105764 @default.
- W2001904531 cites W2067113295 @default.
- W2001904531 cites W2077468629 @default.
- W2001904531 cites W2084472730 @default.
- W2001904531 cites W2086436146 @default.
- W2001904531 cites W2089450477 @default.
- W2001904531 cites W2102642039 @default.
- W2001904531 cites W2104010513 @default.
- W2001904531 cites W2105086774 @default.
- W2001904531 cites W2106591690 @default.
- W2001904531 cites W2107277218 @default.
- W2001904531 cites W2110146284 @default.
- W2001904531 cites W2112889163 @default.
- W2001904531 cites W2115341926 @default.
- W2001904531 cites W2116547987 @default.
- W2001904531 cites W2118571557 @default.
- W2001904531 cites W2119985934 @default.
- W2001904531 cites W2121124015 @default.
- W2001904531 cites W2122057254 @default.
- W2001904531 cites W2125273474 @default.
- W2001904531 cites W2129071472 @default.
- W2001904531 cites W2130347002 @default.
- W2001904531 cites W2131360673 @default.
- W2001904531 cites W2132968779 @default.
- W2001904531 cites W2133982451 @default.
- W2001904531 cites W2134692718 @default.
- W2001904531 cites W2135376726 @default.
- W2001904531 cites W2139139966 @default.
- W2001904531 cites W2142731321 @default.
- W2001904531 cites W2144099695 @default.