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• W2001909498 abstract "ObjectiveTo evaluate the impact of hormone replacement therapy and oral contraceptives containing different progestogens on adiponectin and leptin serum levels.DesignProspective, longitudinal, semi-randomized study.SettingGeneral gynecology clinic of a university hospital.Patient(s)Forty-five healthy postmenopausal and 45 healthy premenopausal women.Intervention(s)Thirty postmenopausal women were randomized to receive either drospirenone (DRSP) 2 mg + E2 1 mg (n = 15) or norethisterone acetate (NETA) 0.5 mg + E2 1 mg (n = 15). Thirty premenopausal women were randomized to receive either ethinilestradiol (EE) 0.020 mg + DRSP 3 mg (n = 15) or EE 0.020 mg + desogestrel 0.15 mg (n = 15). Furthermore, 15 postmenopausal and 15 premenopausal untreated women served as controls.Main Outcome Measure(s)Adiponectin and leptin serum levels before and after 6 months of hormonal therapy.Result(s)No significant differences in leptin levels were detected in any group after 6 months. Adiponectin levels were significantly reduced in the NETA + E2 group and increased in the EE + DRSP group, while remaining unmodified in all other groups.Conclusion(s)Hormone replacement therapy with NETA, but not with DRSP, decreases serum adiponectin levels. Oral contraceptives containing DRSP increase serum adiponectin levels. To evaluate the impact of hormone replacement therapy and oral contraceptives containing different progestogens on adiponectin and leptin serum levels. Prospective, longitudinal, semi-randomized study. General gynecology clinic of a university hospital. Forty-five healthy postmenopausal and 45 healthy premenopausal women. Thirty postmenopausal women were randomized to receive either drospirenone (DRSP) 2 mg + E2 1 mg (n = 15) or norethisterone acetate (NETA) 0.5 mg + E2 1 mg (n = 15). Thirty premenopausal women were randomized to receive either ethinilestradiol (EE) 0.020 mg + DRSP 3 mg (n = 15) or EE 0.020 mg + desogestrel 0.15 mg (n = 15). Furthermore, 15 postmenopausal and 15 premenopausal untreated women served as controls. Adiponectin and leptin serum levels before and after 6 months of hormonal therapy. No significant differences in leptin levels were detected in any group after 6 months. Adiponectin levels were significantly reduced in the NETA + E2 group and increased in the EE + DRSP group, while remaining unmodified in all other groups. Hormone replacement therapy with NETA, but not with DRSP, decreases serum adiponectin levels. Oral contraceptives containing DRSP increase serum adiponectin levels." @default.
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• W2001909498 date "2011-07-01" @default.
• W2001909498 modified "2023-09-30" @default.
• W2001909498 title "Plasma leptin and adiponectin levels in hormone replacement therapy and contraception: effects of different progestogens" @default.
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• W2001909498 doi "https://doi.org/10.1016/j.fertnstert.2011.05.004" @default.
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