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• W2001915293 abstract "The systemic vasculature is known to undergo marked change in both human and experimental hypertension. The in vitro study of individual cellular components from the blood vessel wall and the regulation of their intracellular biochemical processes will aid in developing an understanding of the pathogenesis of hypertension. Vascular smooth muscle cells derived from the aorta and mesenteric arteries of normotensive and hypertensive rats can be successfully maintained in culture, providing a system free of confounding variables such as blood pressure. To assist in fully understanding the pathophysiology of hypertension, this cell culture model can be used to examine interactions between receptor and ligand, the transduction of an associated signal, characterization of subsequent intracellular responses and ultimately, quantification of a physiological and functional consequence of these events, for example, proliferation. The application of in vitro techniques to hypertension research will continue to contribute new knowledge to increase our understanding of the mechanisms behind the hypertensive disease process.Key words: experimental hypertension, spontaneously hypertensive rat, vascular smooth muscle, aorta, mesenteric arteries, cell culture technique." @default.
• W2001915293 created "2016-06-24" @default.
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• W2001915293 date "1992-04-01" @default.
• W2001915293 modified "2023-09-27" @default.
• W2001915293 title "Cultured smooth muscle approach in the study of hypertension" @default.
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• W2001915293 doi "https://doi.org/10.1139/y92-072" @default.
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