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• W2001921621 abstract "Targeting of therapeutic agents to molecular markers expressed on the surface of cells requiring clinical intervention holds promise to improve specificity of delivery, enhancing therapeutic effects while decreasing potential damage to healthy tissues. Drug targeting to cellular receptors involved in endocytic transport facilitates intracellular delivery, a requirement for a number of therapeutic goals. However, after several decades of experimental design, there is still considerable controversy on the practical outcome of drug targeting strategies. The plethora of factors contributing to the relative efficacy of targeting makes the success of these approaches hardly predictable. Lack of fully specific targets, along with selection of targets with spatial and temporal expression well aligned to interventional requirements, pose difficulties to this process. Selection of adequate sub-molecular target epitopes determines accessibility for anchoring of drug conjugates and bulkier drug carriers, as well as proper signaling for uptake within the cell. Targeting design must adapt to physiological variables of blood flow, disease status, and tissue architecture by accommodating physicochemical parameters such as carrier composition, functionalization, geometry, and avidity. In many cases, opposite features need to meet a balance, e.g., sustained circulation versus efficient targeting, penetration through tissues versus uptake within cells, internalization within endocytic compartment to avoid efflux pumps versus accessibility to molecular targets within the cytosol, etc. Detailed characterization of these complex physiological factors and design parameters, along with a deep understanding of the mechanisms governing the interaction of targeted drugs and carriers with the biological environment, are necessary steps toward achieving efficient drug targeting systems." @default.
• W2001921621 created "2016-06-24" @default.
• W2001921621 creator A5000819682 @default.
• W2001921621 date "2012-12-01" @default.
• W2001921621 modified "2023-10-10" @default.
• W2001921621 title "Challenges in design and characterization of ligand-targeted drug delivery systems" @default.
• W2001921621 cites W1495791112 @default.
• W2001921621 cites W1520733676 @default.
• W2001921621 cites W1576210721 @default.
• W2001921621 cites W1593511862 @default.
• W2001921621 cites W1963556560 @default.
• W2001921621 cites W1965600613 @default.
• W2001921621 cites W1967587058 @default.
• W2001921621 cites W1968970438 @default.
• W2001921621 cites W1974158357 @default.
• W2001921621 cites W1975828910 @default.
• W2001921621 cites W1976658012 @default.
• W2001921621 cites W1976822357 @default.
• W2001921621 cites W1977379679 @default.
• W2001921621 cites W1979189978 @default.
• W2001921621 cites W1979558473 @default.
• W2001921621 cites W1980863845 @default.
• W2001921621 cites W1985048358 @default.
• W2001921621 cites W1987534225 @default.
• W2001921621 cites W1990556507 @default.
• W2001921621 cites W1993199678 @default.
• W2001921621 cites W1994044046 @default.
• W2001921621 cites W1994723563 @default.
• W2001921621 cites W1996629582 @default.
• W2001921621 cites W1997270466 @default.
• W2001921621 cites W1998133235 @default.
• W2001921621 cites W1999487245 @default.
• W2001921621 cites W2002993034 @default.
• W2001921621 cites W2003311493 @default.
• W2001921621 cites W2005007331 @default.
• W2001921621 cites W2006012000 @default.
• W2001921621 cites W2006982538 @default.
• W2001921621 cites W2008028087 @default.
• W2001921621 cites W2008644522 @default.
• W2001921621 cites W2010739774 @default.
• W2001921621 cites W2013596208 @default.
• W2001921621 cites W2013768689 @default.
• W2001921621 cites W2015497529 @default.
• W2001921621 cites W2017283061 @default.
• W2001921621 cites W2019207861 @default.
• W2001921621 cites W2019669991 @default.
• W2001921621 cites W2020451319 @default.
• W2001921621 cites W2023268526 @default.
• W2001921621 cites W2024420787 @default.
• W2001921621 cites W2025629542 @default.
• W2001921621 cites W2027022352 @default.
• W2001921621 cites W2029532796 @default.
• W2001921621 cites W2030522563 @default.
• W2001921621 cites W2030855909 @default.
• W2001921621 cites W2033048770 @default.
• W2001921621 cites W2034791477 @default.
• W2001921621 cites W2038054558 @default.
• W2001921621 cites W2039872518 @default.
• W2001921621 cites W2040503264 @default.
• W2001921621 cites W2041759339 @default.
• W2001921621 cites W2043046278 @default.
• W2001921621 cites W2044676804 @default.
• W2001921621 cites W2046666360 @default.
• W2001921621 cites W2048674403 @default.
• W2001921621 cites W2051996732 @default.
• W2001921621 cites W2055233461 @default.
• W2001921621 cites W2055755227 @default.
• W2001921621 cites W2056093518 @default.
• W2001921621 cites W2064761355 @default.
• W2001921621 cites W2066892610 @default.
• W2001921621 cites W2066986283 @default.
• W2001921621 cites W2069960467 @default.
• W2001921621 cites W2070003597 @default.
• W2001921621 cites W2072202404 @default.
• W2001921621 cites W2078080940 @default.
• W2001921621 cites W2078366932 @default.
• W2001921621 cites W2078367209 @default.
• W2001921621 cites W2079335891 @default.
• W2001921621 cites W2081190482 @default.
• W2001921621 cites W2081971022 @default.
• W2001921621 cites W2083483697 @default.
• W2001921621 cites W2083764503 @default.
• W2001921621 cites W2088119617 @default.
• W2001921621 cites W2089773350 @default.
• W2001921621 cites W2089909382 @default.
• W2001921621 cites W2092201159 @default.
• W2001921621 cites W2094586624 @default.
• W2001921621 cites W2095393642 @default.
• W2001921621 cites W2095799297 @default.
• W2001921621 cites W2097778362 @default.
• W2001921621 cites W2100446922 @default.
• W2001921621 cites W2104558356 @default.
• W2001921621 cites W2110569992 @default.
• W2001921621 cites W2111003725 @default.
• W2001921621 cites W2111115146 @default.
• W2001921621 cites W2113572683 @default.
• W2001921621 cites W2113813607 @default.
• W2001921621 cites W2114494901 @default.

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