FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001930809> ?p ?o ?g. }

• W2001930809 endingPage "1013" @default.
• W2001930809 startingPage "1007" @default.
• W2001930809 abstract "The effects of beta-endorphin (lipotropin 61-91) and related naturally-occurring peptides upon acetylcholinesterase activity in rat hind-limb muscles was investigated. beta-endorphin weakly inhibited the activity in a plasma membrane-enriched fraction. The inhibition by beta-endorphin of the membrane-associated acetylcholinesterase was less marked when the fractions were prepared from muscles which had been denervated 4-6 days previously. The membrane-associated acetylcholinesterase was solubilised from normal muscle preparations and separated by sucrose density gradient centrifugation into three major peaks (16S, 10S and 4S). beta-Endorphin inhibited the activity in the 16S peak but not that in the 10S and 4S peaks, whilst tensilon, a competitive inhibitor of acetylcholinesterase, inhibited the activity of all three peaks. beta-Endorphin inhibited the activity in the 16S peak but not that in the 10S and 4S peaks, whilst tensilon, a competitive inhibitor of acetylcholinesterase, inhibited the activity of all three peaks. beta-Endorphin inhibited the 16S activity in a concentration-dependent manner and its action was partly prevented if naloxone was added simultaneously. Purified natural porcine and bovine beta-endorphin were equipotent in terms of effective concentration range but the maximum inhibition was greater with the bovine peptide. beta-Lipotropin was approximately 4 times less potent than beta-endorphin, whilst C-fragment (lipotropin 61-87) was 100 times less potent. Prolonged treatment with collagenase did not reduce the catalytic activity of 16S acetylcholinesterase, but it was no longer susceptible to the inhibitory action of beta-endorphin. Kinetic studies indicated a complex type of inhibition by beta-endorphin (hyperbolic Lineweaver-Burke plot). Methionine enkephalin inhibited acetylcholinesterase in a weakly non-competitive manner and its action was not abolished if the enzyme was predigested with collagenase. beta-Endorphin produces a novel form of inhibition of acetylcholinesterase, acting only on the 16S (A12 or 'motor endplate-specific') form of the enzyme. The findings are discussed in the light of evidence that beta-endorphin-related immunoreactivity is expressed in motor nerve axons in the immature rat." @default.
• W2001930809 created "2016-06-24" @default.
• W2001930809 creator A5079528416 @default.
• W2001930809 creator A5084708788 @default.
• W2001930809 date "1982-04-01" @default.
• W2001930809 modified "2023-09-26" @default.
• W2001930809 title "Selective inhibition of ‘motor endplate-specific’ acetylcholinesterase by β-endorphin and related peptides" @default.
• W2001930809 cites W1775749144 @default.
• W2001930809 cites W1968989693 @default.
• W2001930809 cites W1970902024 @default.
• W2001930809 cites W1971048984 @default.
• W2001930809 cites W1971207503 @default.
• W2001930809 cites W1993508650 @default.
• W2001930809 cites W1994788424 @default.
• W2001930809 cites W1996589380 @default.
• W2001930809 cites W1999316412 @default.
• W2001930809 cites W2000825579 @default.
• W2001930809 cites W2015473709 @default.
• W2001930809 cites W2028185631 @default.
• W2001930809 cites W2040494904 @default.
• W2001930809 cites W2049057570 @default.
• W2001930809 cites W2049480677 @default.
• W2001930809 cites W2054522643 @default.
• W2001930809 cites W2054951528 @default.
• W2001930809 cites W2055560376 @default.
• W2001930809 cites W2083799894 @default.
• W2001930809 cites W2100818755 @default.
• W2001930809 cites W2308255954 @default.
• W2001930809 cites W2330976475 @default.
• W2001930809 cites W2409183230 @default.
• W2001930809 doi "https://doi.org/10.1016/0306-4522(82)90057-4" @default.
• W2001930809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6285223" @default.
• W2001930809 hasPublicationYear "1982" @default.
• W2001930809 type Work @default.
• W2001930809 sameAs 2001930809 @default.
• W2001930809 citedByCount "24" @default.
• W2001930809 countsByYear W20019308092013 @default.
• W2001930809 crossrefType "journal-article" @default.
• W2001930809 hasAuthorship W2001930809A5079528416 @default.
• W2001930809 hasAuthorship W2001930809A5084708788 @default.
• W2001930809 hasConcept C126322002 @default.
• W2001930809 hasConcept C134018914 @default.
• W2001930809 hasConcept C150757390 @default.
• W2001930809 hasConcept C170493617 @default.
• W2001930809 hasConcept C181199279 @default.
• W2001930809 hasConcept C185592680 @default.
• W2001930809 hasConcept C2777544248 @default.
• W2001930809 hasConcept C2778394429 @default.
• W2001930809 hasConcept C2778750930 @default.
• W2001930809 hasConcept C2778816929 @default.
• W2001930809 hasConcept C2781063702 @default.
• W2001930809 hasConcept C55493867 @default.
• W2001930809 hasConcept C71924100 @default.
• W2001930809 hasConcept C86803240 @default.
• W2001930809 hasConcept C98274493 @default.
• W2001930809 hasConceptScore W2001930809C126322002 @default.
• W2001930809 hasConceptScore W2001930809C134018914 @default.
• W2001930809 hasConceptScore W2001930809C150757390 @default.
• W2001930809 hasConceptScore W2001930809C170493617 @default.
• W2001930809 hasConceptScore W2001930809C181199279 @default.
• W2001930809 hasConceptScore W2001930809C185592680 @default.
• W2001930809 hasConceptScore W2001930809C2777544248 @default.
• W2001930809 hasConceptScore W2001930809C2778394429 @default.
• W2001930809 hasConceptScore W2001930809C2778750930 @default.
• W2001930809 hasConceptScore W2001930809C2778816929 @default.
• W2001930809 hasConceptScore W2001930809C2781063702 @default.
• W2001930809 hasConceptScore W2001930809C55493867 @default.
• W2001930809 hasConceptScore W2001930809C71924100 @default.
• W2001930809 hasConceptScore W2001930809C86803240 @default.
• W2001930809 hasConceptScore W2001930809C98274493 @default.
• W2001930809 hasIssue "4" @default.
• W2001930809 hasLocation W20019308091 @default.
• W2001930809 hasLocation W20019308092 @default.
• W2001930809 hasOpenAccess W2001930809 @default.
• W2001930809 hasPrimaryLocation W20019308091 @default.
• W2001930809 hasRelatedWork W1603203920 @default.
• W2001930809 hasRelatedWork W1971852532 @default.
• W2001930809 hasRelatedWork W2001930809 @default.
• W2001930809 hasRelatedWork W2039084986 @default.
• W2001930809 hasRelatedWork W2057262151 @default.
• W2001930809 hasRelatedWork W2087338101 @default.
• W2001930809 hasRelatedWork W2088121632 @default.
• W2001930809 hasRelatedWork W2094143912 @default.
• W2001930809 hasRelatedWork W2118070764 @default.
• W2001930809 hasRelatedWork W2162607362 @default.
• W2001930809 hasVolume "7" @default.
• W2001930809 isParatext "false" @default.
• W2001930809 isRetracted "false" @default.
• W2001930809 magId "2001930809" @default.
• W2001930809 workType "article" @default.