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- W2001931788 abstract "The effects of ferrous ions (Fe2+) on taurine-induced Cl− current (Itau) recorded from single neurons, which was freshly isolated from the rat hippocampal CA1 area, were studied with conventional whole-cell recording under voltage-clamp conditions. Using standard pharmacological approaches, we found that the currents gated by concentrations of taurine (≤10 mM), which existed in about 90% of the hippocampal neurons tested, were predominantly mediated by strychnine-sensitive glycine receptors. When co-applied with taurine, Fe2+ effectively depressed Itau in a concentration-dependent manner, with an IC50 of 3.76 mM and Hill coefficient of 1.01, while preincubation with 1 mM Fe2+ alone did not affect the following membrane currents elicited by taurine. The result suggests that resting taurine-gated channels are insensitive to Fe2+. Since internal cell dialysis with 3 mM Fe2+ failed to modify Itau, it was deduced that the site of action of Fe2+ is extracellular. Furthermore, the Lineweaver–Burke double reciprocal plot of normalized response to taurine against the concentration of taurine illustrated that the depression of Itau was noncompetitive, therefore Fe2+ may act on the glycine receptor–chloride ionophore complex at a site distinct from where taurine binds. Various concentrations of Fe2+ ranging from 0.1 to 20 mM depressed Itau and this extracellular depression was independent of membrane voltage. These results indicate that Fe2+ decreases Itau in acutely dissociated rat hippocampal neurons and the inhibition of glycine receptors by Fe2+ might be one possible approach through which Fe2+ induces seizures." @default.
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- W2001931788 date "2003-01-01" @default.
- W2001931788 modified "2023-09-25" @default.
- W2001931788 title "Fe2+ decreases the taurine-induced Cl− current in acutely dissociated rat hippocampal neurons" @default.
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- W2001931788 doi "https://doi.org/10.1016/s0006-8993(02)03736-8" @default.
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