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- W2001933384 abstract "Lomofungin inhibition of yeast growth and RNA synthesis is prevented by Cu++ or Zn++ ions which chelate with the antibiotic and prevent its uptake by the cells. EDTA potentiates the inhibition. Mg++ ions do not protect in vivo or against the inhibition of purified bacterial RNA and DNA polymerases. Lomofungin prevents formation of the RNA polymerase. DNA initiation complex, probably by chelation with the firmly bound Zn++ of the enzyme." @default.
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- W2001933384 date "1974-10-01" @default.
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- W2001933384 title "Chelation of divalent cations by lomofungin: Role in inhibition of nucleic acid synthesis" @default.
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- W2001933384 doi "https://doi.org/10.1016/0006-291x(74)90405-7" @default.
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