FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001935103> ?p ?o ?g. }

• W2001935103 endingPage "1228" @default.
• W2001935103 startingPage "1222" @default.
• W2001935103 abstract "Recently, data which prove that Wnt pathway activation may be an early event in multistep carcinogenesis in the stomach have been accumulating. We examined the effect of flavanone against beta-catenin/Tcf signaling in AGS gastric cancer cells. Reporter gene assay showed that flavanone inhibited beta-catenin/Tcf signaling efficiently. In addition, the inhibition of beta-catenin/Tcf signaling by flavanone in HEK293 cells transiently transfected with constitutively mutant beta-catenin gene, whose product is not phosphorylated by GSK3beta, indicates that its inhibitory mechanism was related to beta-catenin itself or downstream components. To investigate the precise inhibitory mechanism, we performed immunofluorescence, Western blot, and EMSA. As a result, our data revealed that there is no change of beta-catenin distribution and of nuclear beta-catenin levels through flavanone. In addition, the binding of Tcf complexes to DNA is not influenced by flavanone. The beta-catenin/Tcf transcriptional target gene cyclinD1 was downregulated by flavanone. These data suggest that flavanone inhibits the transcription of beta-catenin/Tcf responsive genes, by modulating Tcf activity without disrupting beta-catenin/Tcf complex formation." @default.
• W2001935103 created "2016-06-24" @default.
• W2001935103 creator A5005697972 @default.
• W2001935103 creator A5013570464 @default.
• W2001935103 creator A5047045237 @default.
• W2001935103 creator A5074170620 @default.
• W2001935103 creator A5080197428 @default.
• W2001935103 date "2005-06-01" @default.
• W2001935103 modified "2023-10-03" @default.
• W2001935103 title "Inhibition of β-catenin-mediated transactivation by flavanone in AGS gastric cancer cells" @default.
• W2001935103 cites W144641193 @default.
• W2001935103 cites W1554815317 @default.
• W2001935103 cites W1936593340 @default.
• W2001935103 cites W1948533188 @default.
• W2001935103 cites W1967137553 @default.
• W2001935103 cites W1972659626 @default.
• W2001935103 cites W1979189704 @default.
• W2001935103 cites W1987829448 @default.
• W2001935103 cites W2000032092 @default.
• W2001935103 cites W2002404925 @default.
• W2001935103 cites W2007251848 @default.
• W2001935103 cites W2009028105 @default.
• W2001935103 cites W2030734078 @default.
• W2001935103 cites W2045939602 @default.
• W2001935103 cites W2050414776 @default.
• W2001935103 cites W2055318170 @default.
• W2001935103 cites W2057517652 @default.
• W2001935103 cites W2068004114 @default.
• W2001935103 cites W2080740523 @default.
• W2001935103 cites W2081985759 @default.
• W2001935103 cites W2085198409 @default.
• W2001935103 cites W2094544968 @default.
• W2001935103 cites W2103635373 @default.
• W2001935103 cites W2130705422 @default.
• W2001935103 cites W2149268447 @default.
• W2001935103 cites W2158944838 @default.
• W2001935103 cites W2159429612 @default.
• W2001935103 cites W2171284757 @default.
• W2001935103 cites W2239090104 @default.
• W2001935103 cites W4255109328 @default.
• W2001935103 doi "https://doi.org/10.1016/j.bbrc.2005.03.242" @default.
• W2001935103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15883006" @default.
• W2001935103 hasPublicationYear "2005" @default.
• W2001935103 type Work @default.
• W2001935103 sameAs 2001935103 @default.
• W2001935103 citedByCount "30" @default.
• W2001935103 countsByYear W20019351032012 @default.
• W2001935103 countsByYear W20019351032013 @default.
• W2001935103 countsByYear W20019351032014 @default.
• W2001935103 countsByYear W20019351032015 @default.
• W2001935103 countsByYear W20019351032016 @default.
• W2001935103 countsByYear W20019351032017 @default.
• W2001935103 countsByYear W20019351032020 @default.
• W2001935103 countsByYear W20019351032021 @default.
• W2001935103 countsByYear W20019351032023 @default.
• W2001935103 crossrefType "journal-article" @default.
• W2001935103 hasAuthorship W2001935103A5005697972 @default.
• W2001935103 hasAuthorship W2001935103A5013570464 @default.
• W2001935103 hasAuthorship W2001935103A5047045237 @default.
• W2001935103 hasAuthorship W2001935103A5074170620 @default.
• W2001935103 hasAuthorship W2001935103A5080197428 @default.
• W2001935103 hasConcept C104317684 @default.
• W2001935103 hasConcept C1292079 @default.
• W2001935103 hasConcept C137620995 @default.
• W2001935103 hasConcept C153911025 @default.
• W2001935103 hasConcept C185592680 @default.
• W2001935103 hasConcept C2776415932 @default.
• W2001935103 hasConcept C2777481717 @default.
• W2001935103 hasConcept C2778004101 @default.
• W2001935103 hasConcept C2779054382 @default.
• W2001935103 hasConcept C2779324961 @default.
• W2001935103 hasConcept C30145163 @default.
• W2001935103 hasConcept C54009773 @default.
• W2001935103 hasConcept C55493867 @default.
• W2001935103 hasConcept C62478195 @default.
• W2001935103 hasConcept C86339819 @default.
• W2001935103 hasConcept C86803240 @default.
• W2001935103 hasConcept C95444343 @default.
• W2001935103 hasConceptScore W2001935103C104317684 @default.
• W2001935103 hasConceptScore W2001935103C1292079 @default.
• W2001935103 hasConceptScore W2001935103C137620995 @default.
• W2001935103 hasConceptScore W2001935103C153911025 @default.
• W2001935103 hasConceptScore W2001935103C185592680 @default.
• W2001935103 hasConceptScore W2001935103C2776415932 @default.
• W2001935103 hasConceptScore W2001935103C2777481717 @default.
• W2001935103 hasConceptScore W2001935103C2778004101 @default.
• W2001935103 hasConceptScore W2001935103C2779054382 @default.
• W2001935103 hasConceptScore W2001935103C2779324961 @default.
• W2001935103 hasConceptScore W2001935103C30145163 @default.
• W2001935103 hasConceptScore W2001935103C54009773 @default.
• W2001935103 hasConceptScore W2001935103C55493867 @default.
• W2001935103 hasConceptScore W2001935103C62478195 @default.
• W2001935103 hasConceptScore W2001935103C86339819 @default.
• W2001935103 hasConceptScore W2001935103C86803240 @default.
• W2001935103 hasConceptScore W2001935103C95444343 @default.
• W2001935103 hasIssue "4" @default.
• W2001935103 hasLocation W20019351031 @default.
• W2001935103 hasLocation W20019351032 @default.

• next