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• W2001940908 abstract "Biological effects of HIV-1 Vpr on CD4(+) cells were studied by an infection system. High-titered HIV-1 stocks pseudotyped with vesicular stomatitis virus G protein were prepared and used to inoculate into CD4(+ )T cells at high multiplicity of infection. Both cell- and virion-associated Vpr were demonstrated to arrest the cell cycle at the G2/M phase, and to induce cell apoptosis. Of note, morphologically apoptotic cells were shown to be arrested at the G2/M stage. No appreciable effect of Vpr on the anti-Fas antibody-mediated apoptosis was observed in this system." @default.
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• W2001940908 date "2000-07-01" @default.
• W2001940908 modified "2023-10-16" @default.
• W2001940908 title "Regulation of cell cycle and apoptosis by human immunodeficiency virus type 1 Vpr" @default.
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• W2001940908 doi "https://doi.org/10.1016/s1286-4579(00)01255-7" @default.
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