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• W2001943542 abstract "Gd-EOB-DTPA is a hepatocyte-specific MRI contrast agent. Due to its hepatocyte-specific uptake and paramagnetic properties, functioning areas of the liver exhibit shortening of the T1 relaxation time. We report the potential use of T1 relaxometry of the liver with Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) for estimating the liver function as expressed by the MELD score. 3 T MRI relaxometry was performed before and 20 min after Gd-EOB-DTPA administration. A strong correlation between changes in the T1 relaxometry and the extent of liver disease, expressed by the MELD score, was documented. Reduced liver function correlates with decreased Gd-EOB-DTPA accumulation in the hepatocytes during the hepatobiliary phase. MRI-based T1 relaxometry with Gd-EOB-DTPA may be a useful method for assessing overall and segmental liver function." @default.
• W2001943542 created "2016-06-24" @default.
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• W2001943542 date "2014-07-08" @default.
• W2001943542 modified "2023-10-16" @default.
• W2001943542 title "MRI-based estimation of liver function: Gd-EOB-DTPA-enhanced T1 relaxometry of 3T vs. the MELD score" @default.
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• W2001943542 doi "https://doi.org/10.1038/srep05621" @default.
• W2001943542 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4085628" @default.
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