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- W2001946503 abstract "Abstract The effects of amantadine were investigated on cercal afferent, giant interneurone synapses and on the cell body membrane of the fast coxal depressor motoneurone (D f ), in the cockroach Periplaneta americana . Bath-applied amantadine at concentrations above 2.0 × 10 −5 M significantly reduced the amplitude of unitary and compound epsps recorded by sucrose-gap methods from cercal afferent, giant interneurone synapses in the desheathed sixth abdominal ganglion. Complete block of synaptic transmission was achieved at 1.0 × 10 −3 M amantadine. Synaptic blockade, which was not accompanied by changes in resting potential, was almost fully reversed by washing the ganglion in normal saline. From the dose-dependence of the synaptic blocking action, a Hill coefficient of 0.94 was estimated, indicating that there is no co-operativity in the binding of amantadine to its site of action. Bath-application of amantadine (5.0 × 10 −5 M) resulted in a parallel shift to the right of the dose-response curve for the depolarizing postsynaptic actions of acetylcholine. Nevertheless, even at a concentration of 2.0 × 10 −3 M, amantadine failed to protect the synaptic acetylcholine receptor/ion channel complex from the blocking action of α-bungarotoxin (5.0 × 10 −7 M). In addition, the block by amantadine of the acetylcholine-induced current recorded from the cell body membrane of the fast coxal depressor motoneurone (D f ), was strongly dependent on membrane potential in the range − 120mV to − 70mV. An action of amantadine at the open acetylcholine receptor/ion channel complex is proposed." @default.
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- W2001946503 date "1984-01-01" @default.
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- W2001946503 title "Actions of amantadine at synaptic and extrasynaptic cholinergic receptors in the central nervous system of the cockroach Periplaneta americana" @default.
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- W2001946503 doi "https://doi.org/10.1016/0022-1910(84)90001-5" @default.
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