FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001947730> ?p ?o ?g. }

• W2001947730 endingPage "1105" @default.
• W2001947730 startingPage "1095" @default.
• W2001947730 abstract "Ethionamide has been used for more than 30 years as a second-line chemotherapeutic to treat tuberculosis patients who have developed resistance to first-line drugs, such as isoniazid (INH) and rifampicin. Activation of the pro-drug ethionamide is regulated by the Baeyer-Villiger monooxygenase EthA and the TetR/CamR family repressor EthR, whose open reading frames are separated by 75 bp on the Mycobacterium tuberculosis genome. EthR has been shown to repress transcription of the activator gene ethA by binding to this intergenic region, thus contributing to ethionamide resistance. We have determined the crystal structure of EthR, to 1.7A resolution, revealing a dimeric two-domain molecule with an overall architecture typical for TetR/CamR repressor proteins. A 20A long hydrophobic tunnel-like cavity in the drug-binding domain of EthR is occupied by two 1,4-dioxane molecules, a component of the crystallisation buffer. Comparing the present structure to those of the homologues Staphylococcus aureus QacR and Escherichia coli TetR leads to the hypothesis that the hydrophobic cavity constitutes a binding site for an as yet unknown ligand that might regulate DNA-binding of EthR." @default.
• W2001947730 created "2016-06-24" @default.
• W2001947730 creator A5000226305 @default.
• W2001947730 creator A5016293777 @default.
• W2001947730 creator A5035699579 @default.
• W2001947730 creator A5068451815 @default.
• W2001947730 creator A5080374671 @default.
• W2001947730 creator A5082419731 @default.
• W2001947730 creator A5083614231 @default.
• W2001947730 date "2004-07-01" @default.
• W2001947730 modified "2023-10-09" @default.
• W2001947730 title "Crystal Structure of the TetR/CamR Family Repressor Mycobacterium tuberculosis EthR Implicated in Ethionamide Resistance" @default.
• W2001947730 cites W1520730837 @default.
• W2001947730 cites W1606011614 @default.
• W2001947730 cites W1816644759 @default.
• W2001947730 cites W1881865374 @default.
• W2001947730 cites W1930402573 @default.
• W2001947730 cites W1981137588 @default.
• W2001947730 cites W1981198757 @default.
• W2001947730 cites W1993063963 @default.
• W2001947730 cites W1993707753 @default.
• W2001947730 cites W1995017064 @default.
• W2001947730 cites W2001641653 @default.
• W2001947730 cites W2013083986 @default.
• W2001947730 cites W2015642465 @default.
• W2001947730 cites W2038840577 @default.
• W2001947730 cites W2050942551 @default.
• W2001947730 cites W2053807200 @default.
• W2001947730 cites W2058925610 @default.
• W2001947730 cites W2066171639 @default.
• W2001947730 cites W2075000963 @default.
• W2001947730 cites W2089688015 @default.
• W2001947730 cites W2091563009 @default.
• W2001947730 cites W2095433835 @default.
• W2001947730 cites W2106315897 @default.
• W2001947730 cites W2112200653 @default.
• W2001947730 cites W2114155688 @default.
• W2001947730 cites W2116275717 @default.
• W2001947730 cites W2131590438 @default.
• W2001947730 cites W2135681003 @default.
• W2001947730 cites W2138956992 @default.
• W2001947730 cites W2146320185 @default.
• W2001947730 cites W2160143801 @default.
• W2001947730 cites W2164087631 @default.
• W2001947730 cites W4239023878 @default.
• W2001947730 cites W4323966389 @default.
• W2001947730 doi "https://doi.org/10.1016/j.jmb.2004.06.003" @default.
• W2001947730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15236969" @default.
• W2001947730 hasPublicationYear "2004" @default.
• W2001947730 type Work @default.
• W2001947730 sameAs 2001947730 @default.
• W2001947730 citedByCount "100" @default.
• W2001947730 countsByYear W20019477302012 @default.
• W2001947730 countsByYear W20019477302013 @default.
• W2001947730 countsByYear W20019477302014 @default.
• W2001947730 countsByYear W20019477302015 @default.
• W2001947730 countsByYear W20019477302016 @default.
• W2001947730 countsByYear W20019477302017 @default.
• W2001947730 countsByYear W20019477302018 @default.
• W2001947730 countsByYear W20019477302019 @default.
• W2001947730 countsByYear W20019477302020 @default.
• W2001947730 countsByYear W20019477302021 @default.
• W2001947730 countsByYear W20019477302022 @default.
• W2001947730 countsByYear W20019477302023 @default.
• W2001947730 crossrefType "journal-article" @default.
• W2001947730 hasAuthorship W2001947730A5000226305 @default.
• W2001947730 hasAuthorship W2001947730A5016293777 @default.
• W2001947730 hasAuthorship W2001947730A5035699579 @default.
• W2001947730 hasAuthorship W2001947730A5068451815 @default.
• W2001947730 hasAuthorship W2001947730A5080374671 @default.
• W2001947730 hasAuthorship W2001947730A5082419731 @default.
• W2001947730 hasAuthorship W2001947730A5083614231 @default.
• W2001947730 hasConcept C104317684 @default.
• W2001947730 hasConcept C142724271 @default.
• W2001947730 hasConcept C158448853 @default.
• W2001947730 hasConcept C2776228421 @default.
• W2001947730 hasConcept C2776448121 @default.
• W2001947730 hasConcept C2777274385 @default.
• W2001947730 hasConcept C2777975735 @default.
• W2001947730 hasConcept C2778607973 @default.
• W2001947730 hasConcept C2781069245 @default.
• W2001947730 hasConcept C501593827 @default.
• W2001947730 hasConcept C54355233 @default.
• W2001947730 hasConcept C71924100 @default.
• W2001947730 hasConcept C86339819 @default.
• W2001947730 hasConcept C86803240 @default.
• W2001947730 hasConcept C89423630 @default.
• W2001947730 hasConceptScore W2001947730C104317684 @default.
• W2001947730 hasConceptScore W2001947730C142724271 @default.
• W2001947730 hasConceptScore W2001947730C158448853 @default.
• W2001947730 hasConceptScore W2001947730C2776228421 @default.
• W2001947730 hasConceptScore W2001947730C2776448121 @default.
• W2001947730 hasConceptScore W2001947730C2777274385 @default.
• W2001947730 hasConceptScore W2001947730C2777975735 @default.
• W2001947730 hasConceptScore W2001947730C2778607973 @default.
• W2001947730 hasConceptScore W2001947730C2781069245 @default.
• W2001947730 hasConceptScore W2001947730C501593827 @default.
• W2001947730 hasConceptScore W2001947730C54355233 @default.

• next