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• W2001957580 abstract "The initiation and control of spinal locomotor mechanisms by supraspinal brainstem centers has been studied in many vertebrate species. However there is very little information regarding brainstem-spinal pathways involved in avian locomotion. To undertake these studies, birds (geese or ducks) were placed in a stereotaxic frame and decerebrated under halothane anesthesia. After anesthesia was discontinued, discrete brainstem regions were electrically stimulated. Locomotion could be evoked from several areas within the pontomedullary reticular formation. The stimulus threshold for evoking walking ranged from 25–50 μA at 30–80 Hz (pulse duration 0.5 ms). At slightly higher current strengths (50–100 μA) wing flapping (‘flying’) was initiated. Histological examination of the stimulation sites indicated that the predominant locomotor areas were restricted to the ventromedial gigantocellular reticular formation and a more dorsolateral location within the parvocellular formation. To ascertain whether neurons in these regions of the avian brainstem project directly to the spinal cord, a retrograde fluorescent tracer dye, True blue, was injected into either the cervical or low thoracic spinal cord. Comparing the positions of the retrogradely labeled neurons and the effective locomotor stimulation sites indicated a high degree of overlap. The present results, when compared with previous studies, suggest strong similarities in descending brainstem control of locomotion for all vertebrates." @default.
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• W2001957580 date "1987-01-01" @default.
• W2001957580 modified "2023-09-24" @default.
• W2001957580 title "Stimulation of the pontomedullary reticular formation initiates locomotion in decerebrate birds" @default.
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• W2001957580 doi "https://doi.org/10.1016/0006-8993(87)91406-5" @default.
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