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- W2001973848 abstract "Abstract Critical‐sized defects in bone, whether induced by primary tumor resection, trauma, or selective surgery have in many cases presented insurmountable challenges to the current gold standard treatment for bone repair. The primary purpose of a tissue‐engineered scaffold is to use engineering principles to incite and promote the natural healing process of bone which does not occur in critical‐sized defects. A synthetic bone scaffold must be biocompatible, biodegradable to allow native tissue integration, and mimic the multidimensional hierarchical structure of native bone. In addition to being physically and chemically biomimetic, an ideal scaffold is capable of eluting bioactive molecules (e.g., BMPs, TGF‐βs, etc., to accelerate extracellular matrix production and tissue integration) or drugs (e.g., antibiotics, cisplatin, etc., to prevent undesired biological response such as sepsis or cancer recurrence) in a temporally and spatially controlled manner. Various biomaterials including ceramics, metals, polymers, and composites have been investigated for their potential as bone scaffold materials. However, due to their tunable physiochemical properties, biocompatibility, and controllable biodegradability, polymers have emerged as the principal material in bone tissue engineering. This article briefly reviews the physiological and anatomical characteristics of native bone, describes key technologies in mimicking the physical and chemical environment of bone using synthetic materials, and provides an overview of local drug delivery as it pertains to bone tissue engineering is included. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009" @default.
- W2001973848 created "2016-06-24" @default.
- W2001973848 creator A5002850853 @default.
- W2001973848 creator A5011992307 @default.
- W2001973848 creator A5026784481 @default.
- W2001973848 date "2009-10-12" @default.
- W2001973848 modified "2023-10-18" @default.
- W2001973848 title "Bone tissue engineering: A review in bone biomimetics and drug delivery strategies" @default.
- W2001973848 cites W109551109 @default.
- W2001973848 cites W114135718 @default.
- W2001973848 cites W148631397 @default.
- W2001973848 cites W1525292585 @default.
- W2001973848 cites W1542853031 @default.
- W2001973848 cites W1547433582 @default.
- W2001973848 cites W1548923710 @default.
- W2001973848 cites W1552789914 @default.
- W2001973848 cites W1555330200 @default.
- W2001973848 cites W1566246481 @default.
- W2001973848 cites W1660962859 @default.
- W2001973848 cites W1966218431 @default.
- W2001973848 cites W1967160381 @default.
- W2001973848 cites W1968822620 @default.
- W2001973848 cites W1969361987 @default.
- W2001973848 cites W1969464368 @default.
- W2001973848 cites W1969702715 @default.
- W2001973848 cites W1970463482 @default.
- W2001973848 cites W1970584042 @default.
- W2001973848 cites W1970932568 @default.
- W2001973848 cites W1970967229 @default.
- W2001973848 cites W1971017689 @default.
- W2001973848 cites W1971339046 @default.
- W2001973848 cites W1971896554 @default.
- W2001973848 cites W1972451730 @default.
- W2001973848 cites W1972985924 @default.
- W2001973848 cites W1973708386 @default.
- W2001973848 cites W1975836982 @default.
- W2001973848 cites W1975864427 @default.
- W2001973848 cites W1976537349 @default.
- W2001973848 cites W1977875815 @default.
- W2001973848 cites W1977900423 @default.
- W2001973848 cites W1978257485 @default.
- W2001973848 cites W1978841037 @default.
- W2001973848 cites W1980580755 @default.
- W2001973848 cites W1981607266 @default.
- W2001973848 cites W1982282780 @default.
- W2001973848 cites W1982503468 @default.
- W2001973848 cites W1982769493 @default.
- W2001973848 cites W1982965008 @default.
- W2001973848 cites W1984665266 @default.
- W2001973848 cites W1984862393 @default.
- W2001973848 cites W1985189560 @default.
- W2001973848 cites W1985395264 @default.
- W2001973848 cites W1986170964 @default.
- W2001973848 cites W1987137464 @default.
- W2001973848 cites W1987482585 @default.
- W2001973848 cites W1988827179 @default.
- W2001973848 cites W1989059246 @default.
- W2001973848 cites W1991976751 @default.
- W2001973848 cites W1992154169 @default.
- W2001973848 cites W1992232132 @default.
- W2001973848 cites W1992474907 @default.
- W2001973848 cites W1992801092 @default.
- W2001973848 cites W1992957889 @default.
- W2001973848 cites W1993652436 @default.
- W2001973848 cites W1994214328 @default.
- W2001973848 cites W1994413098 @default.
- W2001973848 cites W1994417406 @default.
- W2001973848 cites W1995037331 @default.
- W2001973848 cites W1995063875 @default.
- W2001973848 cites W1996478699 @default.
- W2001973848 cites W1996709540 @default.
- W2001973848 cites W1996747774 @default.
- W2001973848 cites W1997552417 @default.
- W2001973848 cites W1998837192 @default.
- W2001973848 cites W2000466100 @default.
- W2001973848 cites W2000762413 @default.
- W2001973848 cites W2000904875 @default.
- W2001973848 cites W2001093535 @default.
- W2001973848 cites W2001633027 @default.
- W2001973848 cites W2001821470 @default.
- W2001973848 cites W2002834882 @default.
- W2001973848 cites W2003337783 @default.
- W2001973848 cites W2004113260 @default.
- W2001973848 cites W2004732395 @default.
- W2001973848 cites W2006628222 @default.
- W2001973848 cites W2006803073 @default.
- W2001973848 cites W2008007787 @default.
- W2001973848 cites W2008180011 @default.
- W2001973848 cites W2008499826 @default.
- W2001973848 cites W2008742639 @default.
- W2001973848 cites W2011412003 @default.
- W2001973848 cites W2011702195 @default.
- W2001973848 cites W2012283033 @default.
- W2001973848 cites W2013459939 @default.
- W2001973848 cites W2014023656 @default.
- W2001973848 cites W2014673628 @default.
- W2001973848 cites W2014949387 @default.
- W2001973848 cites W2015756029 @default.