FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001978655> ?p ?o ?g. }

• W2001978655 endingPage "562" @default.
• W2001978655 startingPage "558" @default.
• W2001978655 abstract "New platinum(II) complex of 3,6-diamine-9-[6,6-bis(2-aminohethyl)-1,6-diaminohexyl]acridine, AzaPt, has been synthesised and characterised. Behaviour of AzaPt in solution (protonation and possible self-aggregation phenomena) has been investigated by spectral methods (absorbance and fluorescence) at I = 0.1 M and 25 °C, and the equilibrium parameters of binding to calf thymus DNA have been established. Two different modes of DNA binding by the complex were detected, which depend on the polymer to dye molar ratio (P/D). At relatively low P/D values the mode was interpreted as binding by the polyamine residue external to the base pairs, while at high P/D values the binding corresponds to intercalation of the proflavine residue. Such interpretation is supported by the observed salt effect on binding and the temperature variation of the binding constants, which allowed estimating the ΔH and ΔS values contributions. Spectrophotometric analysis of the long time range binding revealed that AzaPt is involved in a slow reaction, interpreted as an attack by the platinum ion on the nucleobases. The time constant for such interaction was calculated and found to be the same order of magnitude as for processes responsible for the action of anti-tumour drugs that do covalently bind to polynucleotides." @default.
• W2001978655 created "2016-06-24" @default.
• W2001978655 creator A5019634288 @default.
• W2001978655 creator A5032153581 @default.
• W2001978655 creator A5042721185 @default.
• W2001978655 creator A5046529020 @default.
• W2001978655 creator A5070611548 @default.
• W2001978655 creator A5072560497 @default.
• W2001978655 creator A5087101088 @default.
• W2001978655 date "2011-04-01" @default.
• W2001978655 modified "2023-09-26" @default.
• W2001978655 title "DNA binding of a proflavine derivative bearing a platinum hanging residue" @default.
• W2001978655 cites W127867126 @default.
• W2001978655 cites W1490887033 @default.
• W2001978655 cites W1982233717 @default.
• W2001978655 cites W1988653143 @default.
• W2001978655 cites W1989171624 @default.
• W2001978655 cites W2006826463 @default.
• W2001978655 cites W2010710383 @default.
• W2001978655 cites W2014966556 @default.
• W2001978655 cites W2017681697 @default.
• W2001978655 cites W2023331926 @default.
• W2001978655 cites W2026884660 @default.
• W2001978655 cites W2034209080 @default.
• W2001978655 cites W2040461510 @default.
• W2001978655 cites W2043894202 @default.
• W2001978655 cites W2045037933 @default.
• W2001978655 cites W2056116492 @default.
• W2001978655 cites W2059761480 @default.
• W2001978655 cites W2060626621 @default.
• W2001978655 cites W2067878166 @default.
• W2001978655 cites W2069074470 @default.
• W2001978655 cites W2093687460 @default.
• W2001978655 cites W2094566960 @default.
• W2001978655 cites W2094922595 @default.
• W2001978655 cites W2114611012 @default.
• W2001978655 cites W2138520198 @default.
• W2001978655 cites W2149070790 @default.
• W2001978655 cites W2162094156 @default.
• W2001978655 cites W2170672776 @default.
• W2001978655 cites W2318565229 @default.
• W2001978655 cites W2324392028 @default.
• W2001978655 cites W2328935341 @default.
• W2001978655 cites W3136544117 @default.
• W2001978655 cites W67746198 @default.
• W2001978655 doi "https://doi.org/10.1016/j.jinorgbio.2010.12.010" @default.
• W2001978655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21345323" @default.
• W2001978655 hasPublicationYear "2011" @default.
• W2001978655 type Work @default.
• W2001978655 sameAs 2001978655 @default.
• W2001978655 citedByCount "7" @default.
• W2001978655 countsByYear W20019786552012 @default.
• W2001978655 countsByYear W20019786552013 @default.
• W2001978655 countsByYear W20019786552020 @default.
• W2001978655 crossrefType "journal-article" @default.
• W2001978655 hasAuthorship W2001978655A5019634288 @default.
• W2001978655 hasAuthorship W2001978655A5032153581 @default.
• W2001978655 hasAuthorship W2001978655A5042721185 @default.
• W2001978655 hasAuthorship W2001978655A5046529020 @default.
• W2001978655 hasAuthorship W2001978655A5070611548 @default.
• W2001978655 hasAuthorship W2001978655A5072560497 @default.
• W2001978655 hasAuthorship W2001978655A5087101088 @default.
• W2001978655 hasConcept C107824862 @default.
• W2001978655 hasConcept C111921641 @default.
• W2001978655 hasConcept C121332964 @default.
• W2001978655 hasConcept C137824038 @default.
• W2001978655 hasConcept C145148216 @default.
• W2001978655 hasConcept C161790260 @default.
• W2001978655 hasConcept C178790620 @default.
• W2001978655 hasConcept C179104552 @default.
• W2001978655 hasConcept C185581394 @default.
• W2001978655 hasConcept C185592680 @default.
• W2001978655 hasConcept C2776594999 @default.
• W2001978655 hasConcept C30095370 @default.
• W2001978655 hasConcept C32786932 @default.
• W2001978655 hasConcept C43617362 @default.
• W2001978655 hasConcept C518104683 @default.
• W2001978655 hasConcept C552990157 @default.
• W2001978655 hasConcept C55493867 @default.
• W2001978655 hasConcept C61234307 @default.
• W2001978655 hasConcept C62520636 @default.
• W2001978655 hasConcept C71240020 @default.
• W2001978655 hasConcept C91881484 @default.
• W2001978655 hasConcept C98015330 @default.
• W2001978655 hasConceptScore W2001978655C107824862 @default.
• W2001978655 hasConceptScore W2001978655C111921641 @default.
• W2001978655 hasConceptScore W2001978655C121332964 @default.
• W2001978655 hasConceptScore W2001978655C137824038 @default.
• W2001978655 hasConceptScore W2001978655C145148216 @default.
• W2001978655 hasConceptScore W2001978655C161790260 @default.
• W2001978655 hasConceptScore W2001978655C178790620 @default.
• W2001978655 hasConceptScore W2001978655C179104552 @default.
• W2001978655 hasConceptScore W2001978655C185581394 @default.
• W2001978655 hasConceptScore W2001978655C185592680 @default.
• W2001978655 hasConceptScore W2001978655C2776594999 @default.
• W2001978655 hasConceptScore W2001978655C30095370 @default.
• W2001978655 hasConceptScore W2001978655C32786932 @default.
• W2001978655 hasConceptScore W2001978655C43617362 @default.

• next