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- W2001992018 abstract "Summary The cofactor tetrahydrobiopterin (BH4) is required for nitric oxide (NO) production by all nitric oxide synthase (NOS) enzymes and is a key regulator of cellular redox signalling. When BH4 levels become limiting NOS enzymes become ‘uncoupled’ and produce superoxide rather than NO. Endothelial cell BH4 is required for the maintenance of vascular function through NO production, and reduced BH4 levels are associated with vascular dysfunction. Evidence increasingly points to important roles for BH4 and NOS enzymes in other vascular cell types. Leukocytes have a fundamental role in atherosclerosis, and new evidence points to a role in the control of hypertension. Leukocytes are a major site of iNOS expression, and the regulation of this isoform is another mechanism by which BH4 availability may modulate disease. This review provides an overview of BH4 control of NOS function in both endothelial cells and leukocytes in the context of vascular disease and current therapeutic evaluations." @default.
- W2001992018 created "2016-06-24" @default.
- W2001992018 creator A5000195279 @default.
- W2001992018 creator A5069345978 @default.
- W2001992018 date "2012-01-01" @default.
- W2001992018 modified "2023-10-18" @default.
- W2001992018 title "The role of tetrahydrobiopterin in inflammation and cardiovascular disease" @default.
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- W2001992018 cites W1969304333 @default.
- W2001992018 cites W1969435323 @default.
- W2001992018 cites W1972861299 @default.
- W2001992018 cites W1973390641 @default.
- W2001992018 cites W1987686985 @default.
- W2001992018 cites W1988126593 @default.
- W2001992018 cites W1989089149 @default.
- W2001992018 cites W1994135664 @default.
- W2001992018 cites W2004398529 @default.
- W2001992018 cites W2011089437 @default.
- W2001992018 cites W2016443299 @default.
- W2001992018 cites W2016833774 @default.
- W2001992018 cites W2020245957 @default.
- W2001992018 cites W2024848503 @default.
- W2001992018 cites W2026425756 @default.
- W2001992018 cites W2027873788 @default.
- W2001992018 cites W2028671428 @default.
- W2001992018 cites W2033607253 @default.
- W2001992018 cites W2037000455 @default.
- W2001992018 cites W2038547315 @default.
- W2001992018 cites W2038600714 @default.
- W2001992018 cites W2039286084 @default.
- W2001992018 cites W2044764484 @default.
- W2001992018 cites W2045799225 @default.
- W2001992018 cites W2045892365 @default.
- W2001992018 cites W2055247780 @default.
- W2001992018 cites W2063907656 @default.
- W2001992018 cites W2064619021 @default.
- W2001992018 cites W2069153850 @default.
- W2001992018 cites W2070777627 @default.
- W2001992018 cites W2071186420 @default.
- W2001992018 cites W2071718508 @default.
- W2001992018 cites W2073977612 @default.
- W2001992018 cites W2077790464 @default.
- W2001992018 cites W2080788169 @default.
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- W2001992018 cites W2093121242 @default.
- W2001992018 cites W2097791342 @default.
- W2001992018 cites W2100728329 @default.
- W2001992018 cites W2107888488 @default.
- W2001992018 cites W2108988579 @default.
- W2001992018 cites W2109429191 @default.
- W2001992018 cites W2115659530 @default.
- W2001992018 cites W2117185007 @default.
- W2001992018 cites W2119223703 @default.
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- W2001992018 cites W2122515902 @default.
- W2001992018 cites W2124193115 @default.
- W2001992018 cites W2126560446 @default.
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- W2001992018 cites W2131750066 @default.
- W2001992018 cites W2132896349 @default.
- W2001992018 cites W2136257776 @default.
- W2001992018 cites W2141112342 @default.
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- W2001992018 cites W2149429779 @default.
- W2001992018 cites W2149968000 @default.
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- W2001992018 cites W2170665083 @default.
- W2001992018 cites W2171614223 @default.
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- W2001992018 doi "https://doi.org/10.1160/th12-06-0424" @default.
- W2001992018 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5238931" @default.
- W2001992018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23052970" @default.
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