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- W2001992077 endingPage "800" @default.
- W2001992077 startingPage "787" @default.
- W2001992077 abstract "Ca(2+) release-activated Ca(2+) (CRAC) channels, a subfamily of store-operated channels, play an essential role in various diseases such as immune disorders and allergic responses.The successful treatment of these diseases requires the identification of specific inhibitors. So far, a variety of chemical compounds blocking CRAC have been identified; however, they have all turned out to be less specific. Recently two proteins, STIM1 and ORAI1, have been identified as the essential components that fully reconstitute CRAC currents with a similar biophysical fingerprint.These two proteins and their activation process represent direct targets for the application of specific CRAC inhibitors.For drug development, fluorescence microscopy adaptable for high-throughput screening will provide a powerful assay to mechanistically identify potential CRAC inhibitors that act on various stages within the STIM1/ORAI1 activation pathway visualized by fluorescent-tagged proteins." @default.
- W2001992077 created "2016-06-24" @default.
- W2001992077 creator A5019413131 @default.
- W2001992077 creator A5036873870 @default.
- W2001992077 creator A5062754043 @default.
- W2001992077 creator A5078966901 @default.
- W2001992077 date "2008-06-23" @default.
- W2001992077 modified "2023-10-09" @default.
- W2001992077 title "CRAC inhibitors: identification and potential" @default.
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