FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001992334> ?p ?o ?g. }

• W2001992334 endingPage "824" @default.
• W2001992334 startingPage "819" @default.
• W2001992334 abstract "Amyloid precursor protein (APP) plays a central role in the pathogenesis of Alzheimer's disease, as its cleavage generates the Aβ peptide that is toxic to cells. APP is able to bind Cu2+ and reduce it to Cu+ through its copper-binding domain (CuBD). The interaction between Cu2+ and APP leads to a decrease in Aβ production and to alleviation of the symptoms of the disease in mouse models. Structural studies of CuBD have been undertaken in order to better understand the mechanism behind the process. Here, the crystal structure of CuBD in the metal-free form determined to ultrahigh resolution (0.85 Å) is reported. The structure shows that the copper-binding residues of CuBD are rather rigid but that Met170, which is thought to be the electron source for Cu2+ reduction, adopts two different side-chain conformations. These observations shed light on the copper-binding and redox mechanisms of CuBD. The structure of CuBD at atomic resolution provides an accurate framework for structure-based design of molecules that will deplete Aβ production." @default.
• W2001992334 created "2016-06-24" @default.
• W2001992334 creator A5003193918 @default.
• W2001992334 creator A5040944906 @default.
• W2001992334 creator A5062888518 @default.
• W2001992334 creator A5066343783 @default.
• W2001992334 date "2007-09-19" @default.
• W2001992334 modified "2023-10-16" @default.
• W2001992334 title "Structure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolution" @default.
• W2001992334 cites W1484903051 @default.
• W2001992334 cites W1539796472 @default.
• W2001992334 cites W1644122431 @default.
• W2001992334 cites W1707143272 @default.
• W2001992334 cites W1968091975 @default.
• W2001992334 cites W1981008691 @default.
• W2001992334 cites W1986191025 @default.
• W2001992334 cites W1993231460 @default.
• W2001992334 cites W1996995902 @default.
• W2001992334 cites W1997805873 @default.
• W2001992334 cites W2033017137 @default.
• W2001992334 cites W2038012168 @default.
• W2001992334 cites W2038491728 @default.
• W2001992334 cites W2045427549 @default.
• W2001992334 cites W2047172988 @default.
• W2001992334 cites W2075481535 @default.
• W2001992334 cites W2081881251 @default.
• W2001992334 cites W2088933990 @default.
• W2001992334 cites W2112633282 @default.
• W2001992334 cites W2113403117 @default.
• W2001992334 cites W2116275717 @default.
• W2001992334 cites W2120162345 @default.
• W2001992334 cites W2128029480 @default.
• W2001992334 cites W2162815565 @default.
• W2001992334 cites W2168334242 @default.
• W2001992334 cites W2407667455 @default.
• W2001992334 doi "https://doi.org/10.1107/s1744309107041139" @default.
• W2001992334 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2339725" @default.
• W2001992334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17909280" @default.
• W2001992334 hasPublicationYear "2007" @default.
• W2001992334 type Work @default.
• W2001992334 sameAs 2001992334 @default.
• W2001992334 citedByCount "29" @default.
• W2001992334 countsByYear W20019923342012 @default.
• W2001992334 countsByYear W20019923342014 @default.
• W2001992334 countsByYear W20019923342015 @default.
• W2001992334 countsByYear W20019923342016 @default.
• W2001992334 countsByYear W20019923342017 @default.
• W2001992334 countsByYear W20019923342018 @default.
• W2001992334 countsByYear W20019923342019 @default.
• W2001992334 countsByYear W20019923342020 @default.
• W2001992334 countsByYear W20019923342021 @default.
• W2001992334 countsByYear W20019923342022 @default.
• W2001992334 countsByYear W20019923342023 @default.
• W2001992334 crossrefType "journal-article" @default.
• W2001992334 hasAuthorship W2001992334A5003193918 @default.
• W2001992334 hasAuthorship W2001992334A5040944906 @default.
• W2001992334 hasAuthorship W2001992334A5062888518 @default.
• W2001992334 hasAuthorship W2001992334A5066343783 @default.
• W2001992334 hasBestOaLocation W20019923342 @default.
• W2001992334 hasConcept C115624301 @default.
• W2001992334 hasConcept C12554922 @default.
• W2001992334 hasConcept C142724271 @default.
• W2001992334 hasConcept C159985019 @default.
• W2001992334 hasConcept C175156509 @default.
• W2001992334 hasConcept C178790620 @default.
• W2001992334 hasConcept C179104552 @default.
• W2001992334 hasConcept C185592680 @default.
• W2001992334 hasConcept C192562407 @default.
• W2001992334 hasConcept C203014093 @default.
• W2001992334 hasConcept C27523624 @default.
• W2001992334 hasConcept C2779134260 @default.
• W2001992334 hasConcept C2779281246 @default.
• W2001992334 hasConcept C2780942790 @default.
• W2001992334 hasConcept C3019447875 @default.
• W2001992334 hasConcept C31705614 @default.
• W2001992334 hasConcept C43369102 @default.
• W2001992334 hasConcept C47701112 @default.
• W2001992334 hasConcept C502032728 @default.
• W2001992334 hasConcept C544778455 @default.
• W2001992334 hasConcept C55493867 @default.
• W2001992334 hasConcept C55904794 @default.
• W2001992334 hasConcept C71924100 @default.
• W2001992334 hasConcept C8010536 @default.
• W2001992334 hasConcept C86803240 @default.
• W2001992334 hasConceptScore W2001992334C115624301 @default.
• W2001992334 hasConceptScore W2001992334C12554922 @default.
• W2001992334 hasConceptScore W2001992334C142724271 @default.
• W2001992334 hasConceptScore W2001992334C159985019 @default.
• W2001992334 hasConceptScore W2001992334C175156509 @default.
• W2001992334 hasConceptScore W2001992334C178790620 @default.
• W2001992334 hasConceptScore W2001992334C179104552 @default.
• W2001992334 hasConceptScore W2001992334C185592680 @default.
• W2001992334 hasConceptScore W2001992334C192562407 @default.
• W2001992334 hasConceptScore W2001992334C203014093 @default.
• W2001992334 hasConceptScore W2001992334C27523624 @default.
• W2001992334 hasConceptScore W2001992334C2779134260 @default.
• W2001992334 hasConceptScore W2001992334C2779281246 @default.
• W2001992334 hasConceptScore W2001992334C2780942790 @default.

• next