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- W2002000499 abstract "Several constituents of chromaffin granules were quantitatively determined in noradrenaline and adrenaline cells purified from bovine adrenal medulla. As far as secretory peptides are concerned noradrenaline granules contained slightly more secretogranin II, but much less chromogranin A than adrenaline granules. This can be explained by the dependence of the biosynthesis of chromogranin A on corticosteroids. Proteolytic processing of chromogranin A and secretogranin II was higher in noradrenaline cells which was paralleled by a higher content of the prohormone convertase PC2. Noradrenaline granules also contained a higher concentration of the vesicular monoamine transporter (vMAT2). No differences were found for dopamine beta-hydroxylase, prohormone convertase PC1, carboxypeptidase H and synaptophysin. These results indicate that the secretory cocktail of peptides released from these cells differs significantly between adrenaline and noradrenaline storing cells." @default.
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- W2002000499 date "1996-06-01" @default.
- W2002000499 modified "2023-09-27" @default.
- W2002000499 title "Differences in the composition of chromaffin granules in adrenaline and noradrenaline containing cells of bovine adrenal medulla" @default.
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- W2002000499 doi "https://doi.org/10.1016/0304-3940(96)12712-9" @default.
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